Paris saponin V palmitate 98% Purity Natural Product Reference Standard CAS 1459260-68-4 Research Grade Steroidal Saponin Ester

• • Product Overview

    Paris saponin V palmitate (also known as Progenin III palmitate) is a naturally occurring steroidal saponin fatty ester isolated from the rhizomes of Dioscorea cayenensis (a yam species) and also found in Paris polyphylla (chonglou), a medicinal plant used in traditional Chinese medicine . This compound represents a unique structural class where a palmitic acid (C16:0) ester is attached to the parent saponin skeleton.

    • Molecular Formula: C₅₅H₉₂O₁₃

    • Molecular Weight: 961.31 g/mol

    • Exact Mass: 960.653

    • Appearance: White crystalline powder

    • Density: 1.20 ± 0.1 g/cm³ (Predicted)

    • Boiling Point: 943.6 ± 65.0 °C (Predicted)

    • LogP: 10.3 (Predicted)

    • Hydrogen Bond Donor Count: 5

    • Hydrogen Bond Acceptor Count: 13

    • Rotatable Bond Count: 21

    • Solubility: Soluble in DMSO and pyridine; limited aqueous solubility

    Structural Features

    The key structural modification distinguishing Paris saponin V palmitate from its parent compound is the palmitate ester group attached at the C-6 position of the inner glucose moiety . This esterification significantly increases lipophilicity (LogP predicted to increase from ~2.0–3.5 to ~5.5–7.5), which is a critical determinant of membrane interaction and cellular uptake . The compound is classified as a steroid glycoside ester with a complex spirostan aglycone core featuring multiple stereocenters (21 defined stereocenters) .

    Natural Sources

    Primary source: Dioscorea cayenensis (Guinea yam) rhizomes 
    Also found in: Paris polyphylla (Chinese medicinal plant)

    Biological Significance & Class-Level Activities

    • Lipophilicity Enhancement: The palmitate esterification substantially increases membrane affinity and may enhance passive diffusion across cell membranes, potentially improving intracellular accumulation and altering pharmacokinetic profiles 

    • Hemolytic Activity: Class-level evidence suggests that acylation with a fatty acid chain generally reduces hemolytic activity compared to non-acylated spirostanol saponins, likely due to altered membrane insertion dynamics 

    • Cytotoxicity: While specific cytotoxicity data for this compound are limited, related steroidal saponins from Paris species have demonstrated IC₅₀ values of 0.4–8 mg/L against colon cancer cell lines 

    • Membrane Permeability: The structural modification is non-trivial: it may affect solubility parameters relevant to formulation, necessitate distinct analytical reference standards, and may yield different metabolic stability or tissue distribution profiles in vivo 

    Research Applications

    • Pharmacokinetic Studies: Used to investigate membrane permeability and cellular uptake of acylated saponins 

    • Structure-Activity Relationship Studies: Important reference compound for comparing lipophilicity-dependent biological activities of steroidal saponins

    • Quality Control Reference: Reference standard for HPLC analysis of Paris polyphylla and Dioscorea cayenensis extracts

    • Natural Product Chemistry: Used in structural elucidation and biosynthetic studies of acylated saponins

    Quality Specifications

    • Purity: ≥98.0% determined by HPLC (area normalization)

    • Appearance: White crystalline powder

    • Identification: Confirmed by NMR and mass spectrometry

    • Storage: -20°C for powder (stable up to 3 years); -80°C for solutions (stable up to 1 year)

    • Each batch accompanied by comprehensive Certificate of Analysis (COA)

    Packaging & Storage

    • Packaging: 5mg, 10mg, 20mg, 50mg, 100mg, 500mg, 1g amber glass vials

    • Long-term storage: -20°C, sealed, protected from light and moisture

    • Short-term storage: 2-8°C, sealed, protected from light

    • Solution storage: -80°C for up to 1 year; avoid repeated freeze-thaw cycles 

    • Shipping: Shipped with blue ice or at ambient temperature

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

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