NNMTi/5-Amino-1MQ/Modulates NAD metabolism/longevity research

Description

5-Amino-1-methylquinolinium chloride (abbreviated as 5-Amino-1MQ) is a small-molecule quinolinium salt compound with CAS Number 42464-96-0, molecular formula C₁₀H₁₁ClN₂, and molecular weight 194.6. It belongs to the class of nicotinamide N-methyltransferase (NNMT) inhibitors and is one of the research tools currently attracting attention in the fields of metabolism and anti-aging research. This product is a brown to reddish-brown powder with a purity of ≥98% (as determined by HPLC). It is stable and easy to store, and is primarily used as a research reagent and as a raw material for the development of related products.

Key Benefits

The core mechanism of action of 5-Amino-1MQ lies in the inhibition of nicotinamide N-methyltransferase (NNMT) activity. NNMT is a key enzyme involved in nicotinamide metabolism and is closely associated with processes such as the regulation of intracellular NAD+ levels and energy metabolism in fat cells. By inhibiting NNMT activity, this compound has demonstrated potential for regulating metabolic pathways in relevant studies, making it one of the commonly used tool compounds in the fields of metabolism and anti-aging research.

1. Inhibition of NNMT Enzyme Activity: As an NNMT inhibitor, it suppresses the N-methylation of nicotinamide, making it a core tool for research on this pathway.

2. Regulation of NAD+ Metabolism: By influencing the nicotinamide metabolic pathway, it is closely related to research on the regulation of intracellular NAD+ levels.

3. Lipid Metabolism Research: Studies indicate its relevance to research areas such as energy metabolism in adipocytes and mitochondrial function.

4. Well-Defined Target Specificity: Its inhibitory activity against the NNMT target is well-defined, making it suitable for in-depth mechanistic studies.

Applications

5-Amino-1MQ is primarily used in metabolism-related scientific research and as a raw material in the development of related health products, covering a wide range of research scenarios from enzymatic experiments to cellular and animal models.

1. Enzymology and Mechanism Studies: Used in NNMT enzyme activity inhibition experiments and studies on the mechanisms of action of the nicotinamide metabolic pathway.

2. Cellular and Animal Experiments: Used for research interventions and observations in areas such as lipid metabolism and mitochondrial function.

3. Raw Material for Product Development: Serves as a reference ingredient and raw material for the development of related dietary supplements and health products.

4. Methodological Applications: Can serve as a standard reference compound in the development of analytical methods and the detection of NNMT activity.