Alstonine 98% Purity CAS 642-18-2 Indole Alkaloid for Anticancer and Neuroleptic Research Reagent Grade

• Product Overview

  Alstonine is a naturally occurring indole alkaloid first isolated from species of the genus Alstonia (family Apocynaceae) and also found in Rauvolfia and Picralima species. It belongs to the β-carboline class of alkaloids and is structurally characterized by a tetrahydro-β-carboline core fused with a dihydro-oxepine ring. This product is a high-purity research-grade reagent with a purity of ≥98% as determined by HPLC analysis, appearing as a yellow to off-yellow powder. It is primarily used in anticancer research, neuropsychopharmacology research, and natural product chemistry.

  Chemical Properties

  • Molecular Formula: C₂₁H₂₁N₂O₃ (cation) / C₂₁H₂₀N₂O₃ (free base)

  • Molecular Weight: 349.40 g/mol (free base) / 349.4 g/mol (cation)

  • Synonyms: Alstonine; 3,4,5,6-Tetrahydro-5-(hydroxymethyl)-1-methyl-9H-pyrido[3,4-b]indole-1-carboxylic acid lactone

  • Solubility: Soluble in DMSO, methanol, ethanol

  • UV λmax: 250, 308 nm

  Natural Source

  Alstonine is found in various plant species of the Apocynaceae family, including Alstonia species, Rauvolfia species, and Picralima nitida.

  Biological Activity

  • Anticancer Activity: Alstonine has demonstrated significant anticancer properties in preclinical studies. It exhibits cytotoxic effects against various cancer cell lines and has been studied for its ability to inhibit tumor growth.

  • Neuroleptic-like Activity: Alstonine has been investigated for its neuroleptic-like properties. Studies suggest it may interact with the dopaminergic system and has shown promise in animal models of psychosis.

  • Anxiolytic-like Effects: Research indicates potential anxiolytic-like activity.

  • Natural Product Chemistry: Serves as a reference compound for the study of indole alkaloids and β-carboline derivatives.

  Mechanism of Action

  Alstonine's biological activities are thought to be mediated through modulation of the serotonergic and dopaminergic systems. Its anticancer effects may involve the induction of apoptosis and inhibition of cell proliferation.

  Quality Specifications

  • Purity: ≥98.0% (determined by HPLC area normalization)

  • Appearance: Yellow to off-yellow powder

  • Identification: Conforms to structure by NMR and Mass Spectrometry

  • Loss on Drying: ≤0.5%

  • Residue on Ignition: ≤0.1%

  • Heavy Metals: ≤10 ppm

  • Each batch is accompanied by a comprehensive Certificate of Analysis (COA).

  Packaging & Storage

  • Packaging: Available in 5mg, 10mg, 20mg, 50mg, 100mg amber glass vials for research purposes. Larger quantities are available upon request.

  • Storage: Store powder in a tightly sealed container, protected from light, at 2-8°C for up to 2 years, or at -20°C for up to 3 years.

  • Shelf Life: 36 months when stored under recommended conditions.

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

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