Picralinal 98% Purity CAS 20045-06-1 Indole Alkaloid for Anticancer and Anti-inflammatory Research Reagent Grade

Product Overview

Picralinal is a naturally occurring monoterpenoid indole alkaloid belonging to the corynanthean-type class, first isolated from Picralima nitida and widely distributed in Alstonia scholaris， and other Apocynaceae species . It features a complex hexacyclic framework characterized by an indole moiety fused to a quinolizidine ring system, with a distinctive formyl group at the 16-position . This product is a high-purity research-grade reagent with a purity of ≥98% as determined by HPLC analysis, appearing as a powder . It is primarily used in anti-inflammatory research, natural product chemistry, and pharmaceutical studies.

Chemical Properties

• Molecular Formula: C₂₁H₂₂N₂O₄ 

• Molecular Weight: 366.41 g/mol 

• Synonyms: Picraline, 16-de(acetoxymethyl)-16-formyl-; Methyl (2β,5β,15α,16ξ,19Z)-17-oxo-1,2-dihydro-2,5-epoxyakuammilan-16-carboxylate 

• Density: 1.4±0.1 g/cm³ (Predicted) 

• Boiling Point: 538.6±50.0 °C at 760 mmHg (Predicted) 

• Flash Point: 279.5±30.1 °C 

• Refractive Index: 1.678 

• LogP: 3.33 

• Hydrogen Bond Donors: 1 

• Hydrogen Bond Acceptors: 6 

• Rotatable Bond Count: 3 

• Topological Polar Surface Area: 67.87 Ų 

• Exact Mass: 366.157959 

• InChIKey: RHBAENOZUZWALZ-UHFFFAOYSA-N 

• SMILES: CC=C1CN2C3CC45c6ccccc6NC4(O3)C2CC1C5(C=O)C(=O)OC 

• Solubility: Soluble in chloroform, dichloromethane, ethyl acetate, DMSO, acetone 

Natural Source

Picralinal is a major indole alkaloid found in Alstonia scholaris, a plant widely used in traditional medicine across Asia . It has also been isolated from Picralima nitida (leaves) and other Apocynaceae species . Research has shown that the fruit of Alstonia scholaris contains the highest amounts of picralinal, making it the preferred source for isolation .

Biological Activity & Mechanism of Action

• Anti-inflammatory Activity: Picralinal has been shown to exhibit significant anti-inflammatory and analgesic effects . In a pharmacological evaluation of Alstonia scholaris, picralinal was identified as a COX-2/5-LOX dual inhibitor, suggesting its potential value for further development as an anti-inflammatory agent .

• COX-2/5-LOX Dual Inhibition: Picralinal acts as a dual inhibitor of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), key enzymes in the inflammatory cascade . This dual inhibition profile makes it an attractive candidate for inflammation research.

• Analgesic Effects: In addition to its anti-inflammatory properties, picralinal has demonstrated analgesic effects in pharmacological studies .

Quality Specifications

• Purity: ≥98.0% (determined by HPLC area normalization) 

• Appearance: Powder 

• Identification: Conforms to structure by NMR and Mass Spectrometry

• Loss on Drying: ≤0.5%

• Residue on Ignition: ≤0.1%

• Heavy Metals: ≤10 ppm

• Each batch is accompanied by a comprehensive Certificate of Analysis (COA).

Packaging & Storage

• Packaging: Available in 5mg, 10mg, 20mg, 50mg, 100mg amber glass vials for research purposes. Larger quantities are available upon request .

• Storage: Store powder in a tightly sealed container, protected from light, at 2-8°C for up to 24 months . For stock solutions, store as aliquots at -20°C for up to two weeks . For long-term storage, store at -20°C for up to 3 years or at -80°C for up to 6 months for solutions .

• Shelf Life: 24 months when stored under recommended conditions .

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.