Dimethylfraxetin 98% Purity CAS 6035-49-0 Coumarin Carbonic Anhydrase Inhibitor for Anticancer and Anti-inflammatory Research Reagent Grade

• • Product Overview

    Dimethylfraxetin, also known as 6,7,8-trimethoxycoumarin or fraxetin dimethyl ether, is a naturally occurring coumarin compound found in various plant sources including Fraxinus chinensis and Ruta angustifolia . It is a trimethoxy-substituted coumarin derivative. This product is a high-purity research-grade reagent with a purity of ≥98% as determined by HPLC analysis, appearing as a white to off-white crystalline solid . It is primarily used in anticancer research, anti-inflammatory research, and natural product chemistry.

    Chemical Properties

    • Molecular Formula: C₁₂H₁₂O₅ 

    • Molecular Weight: 236.22 g/mol 

    • Synonyms: 6,7,8-Trimethoxycoumarin; Fraxetin dimethyl ether; O,O-Dimethylfraxetin 

    • Melting Point: 104-105°C 

    • Boiling Point: 338.68°C (rough estimate) 

    • Density: 1.249 

    • Refractive Index: 1.5140 (estimate) 

    • InChIKey: RAYQKHLZHPFYEJ-UHFFFAOYSA-N 

    • SMILES: C1(=O)OC2=C(OC)C(OC)=C(OC)C=C2C=C1 

    • Solubility: Soluble in DMSO (125 mg/mL), methanol, ethanol 

    Natural Source

    Dimethylfraxetin is found in Fraxinus chinensis and Ruta angustifolia, among other plant sources .

    Biological Activity

    • Carbonic Anhydrase Inhibition: Dimethylfraxetin is a potent carbonic anhydrase inhibitor with a Ki value of 0.0097 μM. It is the most potent of the natural product coumarins tested across six CA isozymes, particularly against CA I .

    • Anticancer Activity: Has been studied for its anti-tumor properties .

    • Anti-inflammatory Activity: Exhibits anti-inflammatory effects .

    • Immunomodulatory Activity: Research suggests it may enhance immune function .

    • Anti-radiation Activity: Shows potential protective effects against radiation damage .

    Quality Specifications

    • Purity: ≥98.0% (determined by HPLC area normalization) 

    • Appearance: White to off-white crystalline solid 

    • Identification: Conforms to structure by NMR and Mass Spectrometry

    • Loss on Drying: ≤0.5%

    • Residue on Ignition: ≤0.1%

    • Heavy Metals: ≤10 ppm

    • Each batch is accompanied by a comprehensive Certificate of Analysis (COA).

    Packaging & Storage

    • Packaging: Available in 2mg, 5mg, 10mg, 20mg, 50mg, 100mg amber glass vials for research purposes. Larger quantities are available upon request.

    • Storage: Store in a tightly sealed container, protected from light, at 2-8°C .

    • Shelf Life: 24 months when stored under recommended conditions.

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.