Retatrutide peptide /appetite, energy balance/Obesity and type 2 diabetes research

Product Description

Retatrutide is a synthetic peptide compound with the development code LY3437943, CAS Number 2381089-83-2, molecular formula C₂₂₁H₃₄₂N₄₆O₆₈, and molecular weight 4731.33. It belongs to a new generation of “triple receptor agonist” peptides capable of simultaneously acting on three key receptors in the human body that are closely related to energy metabolism, making it a highly sought-after compound in the field of metabolic research in recent years. This product is supplied as a high-purity (≥99%, as determined by HPLC) lyophilized powder. It is stable, easy to store, and convenient for experimental preparation, and can be used directly in various scientific research experiments. 

Key Benefits

The most distinctive feature of Retatrutide lies in its “one drug, three targets” mechanism of action. It simultaneously activates the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR)—all three of which play key roles in metabolic processes such as appetite regulation, energy expenditure, and blood glucose stabilization. Data from multiple research projects indicate that this compound has demonstrated significant regulatory effects on body weight and glucose metabolism in relevant experimental models, and is therefore regarded as a representative research tool among triple-agonist peptides.

1. Synergistic activation of three receptors: Simultaneously agonizing the GLP-1R, GIPR, and GCGR receptors to achieve multi-pathway synergistic regulation—this is its core advantage over dual-target agonists.

2. Body weight regulation: A marked reduction in body weight was observed in animal models such as diet-induced obesity (DIO).

3. Glucose metabolism regulation: Experimental data show that it improves glucose control, providing important reference value for research on glucose metabolism.

4. Prolonged duration of action: As a structurally modified peptide analog, it has a long duration of action, making it suitable for long-term observational studies.

Applications

Retatrutide is currently used primarily in scientific research related to metabolic diseases, covering the full spectrum of experimental scenarios from molecular mechanisms to animal models. It serves as a commonly used tool compound in high-profile research areas such as obesity, type 2 diabetes, and non-alcoholic steatohepatitis (MASH), while also providing important reference molecules for the development of a new generation of peptide-based metabolic drugs.

1. Research on the Mechanisms of Metabolic Diseases: Used to explore the pathogenesis and intervention targets of diseases such as obesity, type 2 diabetes, and fatty liver disease.

2. In Vivo Animal Experiments: Suitable for subcutaneous administration and long-term efficacy observation in metabolic disease models (e.g., the DIO obesity model) in mice and rats.

3. Drug Development Reference: As a representative molecule of triple-agonist peptides, it is used in R&D stages such as structural optimization and lead compound screening for novel metabolic drugs.

4. In Vitro Cellular and Molecular Experiments: Can be used for molecular-level experiments such as receptor agonist activity evaluation and downstream signaling pathway studies.

5. Standard Reference Material: Can serve as a standard reference material for the development of relevant peptide detection methods and quality analysis.