Factory Price Spermidine CAS 124-20-9 Powder 99.9 Spermidine in stock on sale

1. Description

Spermidine trihydrochloride (CAS 334-50-9) is a stable hydrochloride salt of the natural polyamine spermidine; it appears as a white to off-white crystalline powder that is easy to store and transport. Its molecular formula is C₇H₂₂Cl₃N₃, with a molecular weight of 254.63. It is highly soluble in water, with a solubility exceeding 100 mg/mL, and has a melting point of 260–264°C. It is recommended to store it in a dry, sealed container protected from light at -20°C, where it remains stable for extended periods. As a research tool, it exhibits high biological stability.

2. Application

(1) Autophagy and Anti-Aging Research: As a novel autophagy inducer, it serves as a key tool for studying the mechanisms of cellular autophagy, delaying aging, and achieving healthy longevity. By regulating the expression of autophagy-related enzymes and genes, it activates the cell’s “cleansing” mechanism for removing damaged components. Cellular studies demonstrate its ability to effectively induce autophagy. Clinically, a 20-year study of 829 participants found that individuals with a daily intake of >79.8 μmol of spermidine exhibited a significant reduction in all-cause mortality, equivalent to an age advantage of 5.7 years.

(2) Skin Health and Wound Healing: Due to its ability to promote autophagy and its antioxidant effects, it can protect skin cells and improve elasticity and appearance. Regarding wound healing, a rat study found that a carbon quantum dot NO donor developed based on this compound promotes angiogenesis, extracellular matrix organization, and cell migration, thereby accelerating the repair of deep burns.

(3) Cell Culture and Molecular Biology: In non-therapeutic basic research, it is commonly used to promote cell growth and proliferation, such as acting as a supplement to stimulate cell division. Additionally, because it can bind to DNA, it can be applied to stimulate DNA-related enzymes or purify DNA-binding proteins.

(4) Cardiovascular and Metabolic Research: Animal studies have confirmed that supplementation with spermidine enhances cardiac autophagy and mitochondrial function in aged mice, improving both systolic and diastolic function. Epidemiological data similarly indicate a negative correlation between spermidine intake and cardiovascular disease mortality.

(5) Neuroprotective Research: As an NMDA receptor agonist, it exerts neuromodulatory effects by binding to polyamine regulatory sites. It is commonly used in basic research on related diseases and has demonstrated the potential to protect neurons from damage in animal models.

3. Main Efficacy

(1) Powerful Antioxidant and Free Radical Scavenger: L-ergothioneine is a highly effective antioxidant. Its specific transporter, OCTN1, delivers it precisely to the mitochondria—the primary site of reactive oxygen species (ROS) production in cells—thereby eliminating aging factors at their source. It effectively scavenges reactive oxygen species, reducing oxidative damage to DNA, proteins, and cell membranes, thereby helping to slow the aging process and reduce oxidative stress in the body.

(2) Anti-inflammatory and Neuroprotective Effects: By scavenging ROS, inhibiting the expression of neuroinflammatory cytokines (TNF-α, IL-1β, IL-6), activating the Nrf2 antioxidant pathway, and maintaining mitochondrial integrity, it exerts significant neuroprotective effects. Supplementing with ergothioneine may help improve cognitive and memory functions, consistent with its high concentration in easily oxidized organs such as the brain.

(3) Skin Brightening and Anti-Photoaging: It inhibits tyrosinase activity and reduces melanin production, thereby improving uneven skin tone and dark spots. Simultaneously, by scavenging free radicals generated by UV radiation and reducing oxidative stress, it mitigates UV-induced skin damage and aging while enhancing the skin’s barrier function.

(4) Regulation of Cell Signaling and Metabolism: As a specific inhibitor of p38-MAPK and Akt, it suppresses stress-induced apoptosis by regulating related signaling pathways. Additionally, its biological mechanisms involve the regulation of the Keap1-Nrf2-ARE and Sirtuins signaling pathways, as well as the activation of antioxidant enzymes such as SOD, CAT, and GSH-Px, thereby enhancing the body’s defense functions.