weight loss O-304/research reagent (metabolic/diabetes research)/energy metabolism study

product details

Description

This product is an organic compound designated as O-304 (also known as ATX-304), with CAS number 1261289-04-6. Its chemical name is 4-chloro-N-(2-(4-chlorobenzyl)-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)benzamide. The molecular formula of the product is C₁₆H₁₁Cl₂N₃O₂S, and its molecular weight is approximately 380.25. It normally appears as a white to off-white powder with a purity of over 98% (determined by HPLC). As an intermediate and active small-molecule compound for pharmaceutical research and development, this product has attracted considerable research interest in the research and development of drugs for metabolic diseases in recent years. It is mainly supplied to pharmaceutical R&D institutions, research institutes and biotechnology companies. The product is recommended to be stored in a sealed container away from light at 2~8℃ to ensure stable quality during its shelf life.

Key Benefits

The core function of O-304 is to activate a key protein (AMPK) in the human body that is closely associated with the regulation of energy metabolism. AMPK is often likened to the "master energy switch" inside cells. When activated, cells utilize energy more efficiently. O-304 is a small-molecule compound that can effectively turn on this switch. It also features good absorption and utilization after oral administration, so it is widely used in mechanistic research and new drug development for related diseases.

Its specific functions can be summarized as follows:
Activate key proteins for energy metabolism: Effectively boost AMPK activity and help the body improve its energy metabolism;
Promote glucose utilization: Enhance cellular glucose uptake and help improve the body's blood glucose regulation;
Alleviate insulin resistance: Reduce insulin resistance in tissues such as skeletal muscle and improve the body's response to insulin;
Regulate energy expenditure: Increase bodily energy consumption, offering reference value for research on weight and fat accumulation control;
Ease the burden on pancreatic islet cells: Help relieve stress in pancreatic β cells, allowing them to "rest", and provide insights for research on diabetes progression;
Assist in improving cardiovascular indicators: Relevant studies show it can increase peripheral blood flow and improve left ventricular function, exerting partial effects similar to "exercise training".

Applications

O-304 is mainly applied in the field of biomedical research and development, especially focusing on the research of metabolic diseases represented by type 2 diabetes. With its regulatory effect on energy metabolic pathways, this compound has been used by numerous research teams at home and abroad as an experimental tool and a candidate drug research subject. Its scope of application has gradually extended from metabolic diseases to related fields such as cardiovascular and liver disorders.

Its main application areas can be summarized as follows:
Research on type 2 diabetes and insulin resistance: used to explore blood glucose regulation, improvement of insulin sensitivity and the progression mechanism of diabetes;
Research on obesity and energy metabolism: used for studies on obesity-related metabolic disorders, fat accumulation and the regulation of energy expenditure;
Research on liver metabolism including non-alcoholic fatty liver disease: used to investigate the mechanisms underlying abnormal hepatic lipid metabolism and associated lesions;
Research on cardiovascular complications: used in studies of diabetic cardiovascular complications, hemodynamics and cardiac function improvement;
New drug research and efficacy evaluation: used as a lead compound or tool molecule for the screening, evaluation and process development of candidate drugs.