Rotundine, l-Tetrahydropalmatine, l-THP/sedative, hypnotic, dopamine receptor blockade

Description

This product is Rotundine (also known as L-Tetrahydropalmatine), with CAS No. 10097-84-4. It is a natural alkaloid active ingredient extracted and refined from the tuberous roots of Stephania sinica and traditional Chinese medicinal herbs such as Corydalis yanhusuo of the Menispermaceae family, and it is the levoisomer of tetrahydropalmatine, the main active component of the traditional Chinese medicine Corydalis yanhusuo. The molecular formula of the product is C₂₁H₂₅NO₄, and its molecular weight is approximately 355.43. It normally appears as white to off-white crystalline powder, with a purity of over 98% (tested by HPLC). As a mature commercial pharmaceutical raw material, this product can be supplied in different grades including pharmaceutical grade and reagent grade according to application purposes. It is mainly provided to pharmaceutical enterprises, formulation manufacturers and scientific research institutions, and is an alkaloid variety with a long history of clinical application. The product shall be stored in a sealed, light-proof place at cool and dry conditions.

Key Effects

Rotundine is a commonly used analgesic component in traditional Chinese medicine. The generation of pain is closely related to the transmission of certain signals in the nervous system. Rotundine can act on the central nervous system, reduce pain perception by regulating relevant signal transmission, and also exert certain sedative and tranquilizing effects, helping relieve irritability and difficulty falling asleep caused by pain. In clinical applications, it is mainly used for the treatment of headaches, menstrual pain, gastrointestinal colic, and insomnia induced by pain. It is a mild, long-standing non-narcotic analgesic pharmaceutical component and also holds important value in the modernization research of traditional Chinese medicine.

Its specific functions can be summarized as follows:
Pain relief: Acts on the central nervous system to help alleviate headaches, dysmenorrhea, gastrointestinal colic and other pains;
Sedation and tranquilization: Has a certain sedative effect to ease restlessness caused by pain;
Sleep-aiding effect: Can be used for insomnia triggered by pain and other factors to help improve sleep quality;
Active ingredient of traditional Chinese medicine: Serves as a marker component of medicinal herbs such as Corydalis yanhusuo for research on the material basis of pharmacodynamic effects;
Standard substance and reference function: Can be applied to quality control and content determination of related medicinal materials and preparations.

Applications

This product is an alkaloid pharmaceutical raw material derived from traditional Chinese medicine. It is mainly targeted at the production of analgesic pharmaceutical preparations, as well as the research and testing of traditional Chinese medicine, with well-defined application directions.

Its main application fields can be summarized as follows:
Analgesic drug production: Used as an active pharmaceutical ingredient for analgesic medicines treating headache, dysmenorrhea, gastrointestinal pain and other pains;
Sedative and sleep-aiding drugs: Serves as a raw material for medicines that relieve conditions such as insomnia accompanied by pain;
Traditional Chinese medicine research and testing: Applied as a standard substance and reference substance for the quality control of related medicinal materials such as Corydalis Rhizoma;
Natural drug development: Used as an active ingredient in the modernization research of traditional Chinese medicine and natural drug development;
Supply of scientific research reagents: Provided as experimental materials for pharmacological research to universities, research institutes and pharmaceutical laboratories;
Export trade and raw material supply: Supplied as an alkaloid pharmaceutical raw material to pharmaceutical enterprises, research institutions and traders, with specifications available upon customer requirements.