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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Ezetimibe for Sale > Ezetimibe CAS 163222-33-1 Selective Cholesterol Absorption Inhibitor for Hypercholesterolemia fk
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Ezetimibe CAS 163222-33-1 Selective Cholesterol Absorption Inhibitor for Hypercholesterolemia fk

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Unit Price:

$100-130/G FOB

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CAS No.:

163222-33-1

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

10mg, 25mg, 50mg, 100mg, 1g

Sample Available:

Yes

Price valid (until):

2026-10-25

Company Type:
Trader
Location:
China
Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
7 days
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    —— Product Specification ——

    Parameter Specification Details
    Product Name Ezetimibe (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
    CAS Number 163222-33-1 163222-33-1
    Molecular Formula C₂₄H₂₁F₂NO₃ 24 carbons, 21 hydrogens, 2 fluorine, 1 nitrogen, 3 oxygens
    Molecular Weight 409.43 g/mol —
    Appearance White to off-white crystalline powder Visual inspection
    Purity ≥98.0% (USP: 98.0–102.0% on anhydrous basis) Determined by HPLC
    Melting Point 164 – 166°C —
    Solubility Practically insoluble in water; soluble in DMSO, methanol, ethanol —
    Storage Room temperature, protect from light and moisture Sealed containers
    Packaging 100mg, 500mg, 1g, 5g Amber glass vials
    Application Research use only Hypercholesterolemia research, lipid metabolism studies


    —— Product Detail ——

    Product Overview

    Ezetimibe (CAS 163222-33-1), also known as Zetia or Ezetrol, is a novel, orally active, selective cholesterol absorption inhibitor developed by Schering-Plough . It appears as a white to off-white crystalline powder with the molecular formula C₂₄H₂₁F₂NO₃ and a molecular weight of 409.43 g/mol .



    Packaging & Shipping

      • Research quantities: 10mg, 25mg, 50mg amber glass vials

      • Bulk quantities: 100mg, 1g, 5g amber glass bottles

      • Custom packaging available upon request

      • Not classified as hazardous material for transport under normal conditions

      • Product for research and analytical use only; not for human or veterinary use

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    — Company profile ——


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    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

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    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    White SolidEzetimibe is ananti-hyperlipidemic drug used for lowering the plasma cholesterol levels. It is indicated as an adjunctive therapy to diet for the reduction of high-level total-C, LDL-C, and ApoB in patients suffering primary (heterozygous familial and non-familial) hypercholesterolemia. It is also used in combination therapy with HMG-CoA reductase inhibitors.Ezetimibe does not inhibit the cholesterol synthesis in the liver, or increase bile acid excretion.It takes effect throughactin
    Solid
    Ezetimibe is a beta-lactam that is azetidin-2-one which is substituted at 1, 3, and 4 by p-fluorophenyl, 3-(p-fluorophenyl)-3-hydroxypropyl, and 4-hydroxyphenyl groups, respectively (the 3R,3'S,4S enantiomer). It has a role as an anticholesteremic drug, an antilipemic drug and an antimetabolite. It is a member of azetidines, an organofluorine compound and a beta-lactam.|Ezetimibe is a lipid-lowering compound that inhibits intestinal cholesterol and phytosterol absorption. The discovery and research of this drug began in the early 1990s, after the intravenous administration of radiolabelled ezetimibe in rats revealed that it was being localized within enterocytes of the intestinal villi - this prompted studies investigating the effect of ezetimibe on intestinal cholesterol absorption. Ezetimibe is used as an adjunctive therapy to a healthy diet to lower cholesterol levels in primary hyperlipidemia, mixed hyperlipidemia, homozygous familial hypercholesterolemia (HoFH), and homozygous sitosterolemia (phytosterolemia). Unlike other classes of cholesterol-reducing compounds including statins and bile acid sequestrants, ezetimibe has a distinct mechanism of action involving the sterol transporter Niemann-Pick C1-Like 1 (NPC1L1), and is unique in that it does not affect the absorption of fat-soluble nutrients such as fat-soluble vitamins, triglycerides, or bile acids. In genetically NPC1L1-deficient mice, a 70% reduction in intestinal cholesterol absorption was seen, and these mice were insensitive to ezetimibe treatment - it was determined based on these findings that NPC1L1 plays an essential role in promoting intestinal cholesterol uptake via an ezetimibe-sensitive pathway. By interfering with the intestinal uptake of cholesterol and phytosterols, ezetimibe reduces the delivery of intestinal cholesterol to the liver.|Ezetimibe is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.|Ezetimibe is an inhibitor of intestinal cholesterol absorption that is widely used in the therapy of hypercholesterolemia, usually in combination with other agents. Ezetimibe therapy is associated with a low rate of serum aminotransferase elevations and clinically apparent liver injury due to ezetimibe occurs, but is rare.|Ezetimibe is an azetidinone derivative and a cholesterol absorption inhibitor with lipid-lowering activity. Ezetimibe appears to interact physically with cholesterol transporters at the brush border of the small intestine and inhibits the intestinal absorption of cholesterol and related phytosterols. As a result, ezetimibe causes a decrease in the level of blood cholesterol or an increase in the clearance of cholesterol from the bloodstream. Overall, the following effects observed are a reduction of hepatic cholesterol stores and a reduction of total cholesterol, LDL cholesterol, and other triglycerides in the blood.|An azetidine derivative and ANTICHOLESTEREMIC AGENT that inhibits intestinal STEROL absorption. It is used to reduce total CHOLESTEROL; LDL CHOLESTEROL, and APOLIPOPROTEINS B in the treatment of HYPERLIPIDEMIAS.

    Certificates
    • Ezetimibe CAS 163222-33-1 Selective Cholesterol Absorption Inhibitor for Hypercholesterolemia fk Certificates 1 TDS

    Basic Info
    Product Name:

    Ezetimibe

    Other Name:

    2-Azetidinone,1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-,(3R,4S)-;2-Azetidinone,1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-,[3R-[3α(S*),4β]]-;(3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone;Sch 58235;Ezetimibe;(-)-Sch 58235;Zetia;Ezetrol;Ezta;Ezedoc;1-(4-Fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)azetidin-2-one;Ezentia

    CAS No.:

    163222-33-1

    Molecular Formula:

    C24H21F2NO3

    InChIKeys:

    InChIKey=OLNTVTPDXPETLC-XPWALMASSA-N

    Molecular Weight:

    409.43

    Exact Mass:

    409.43

    EC Number:

    1308068-626-2

    UNII:

    EOR26LQQ24

    DSSTox ID:

    DTXSID1044223

    NCI Thesaurus Code:

    C47529

    Color/Form:

    White solid

    ATC Code:

    C10B|C10AX09|C - Cardiovascular system

    HScode:

    29337900

    Characteristics
    PSA:

    60.8

    XLogP3:

    4

    Appearance:

    Solid

    Density:

    1.334±0.06 g/cm3(Predicted)

    Melting Point:

    164-166 °C

    Boiling Point:

    654.9±55.0 °C(Predicted)

    Flash Point:

    349.9±31.5 °C

    Refractive Index:

    1.624

    Water Solubility:

    H2O: Insoluble

    Storage Conditions:

    -20°C Freezer

    Vapor Pressure:

    1.5X10-14 mm Hg at 25 deg C (est)

    Specific rotation:

    D22 -33.9° (c = 3 in methanol)

    Henrys Law Constant:

    Henry's Law constant = 4.4X10-18 atm-cu m/mole at 25 °C (est)

    Dissociation Constants:

    pKa1 = 9.73 (phenol) (est)

    Collision Cross Section:

    213.6 Ų [M+Na]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

    Hazard Identification

    Classification of the substance or mixture

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H410 Very toxic to aquatic life with long lasting effects

    Precautionary statement(s)
    Prevention

    P273 Avoid release to the environment.

    Response

    P391 Collect spillage.

    Storage

    none

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7 days

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Inquiry History
    7 Inquiries
    Country Product Purchase Quantity Date Posted
    India

    Ezetimibe

    5.00 KG Jan 22, 2024
    France

    Ezetimibe

    10 G Sep 29, 2026
    Pakistan

    Ezetimibe

    10 KG Oct 29, 2025
    United States

    Ezetimibe

    10 G Sep 16, 2025
    United States

    Zetia ,Combivent ,Symbicort ,Namenda ,NovoLog FlexPen , Xarelto ,NovoLog ,Humalog , Suboxone ,

    60 MT Oct 12, 2023
    India

    Linagliptin

    5.00 KG Jan 22, 2024
    India

    Febuxostat

    5.00 KG Jan 22, 2024
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