Product Overview

4-Hydrazinylbenzenesulfonamide hydrochloride (CAS 17852-52-7) is an aryl hydrazine derivative of benzenesulfonamide, supplied as a white to light yellow crystalline powder. It is a key building block in the synthesis of celecoxib and related COX-2 inhibitor scaffolds, and is also used in agrochemical and dyestuff intermediate chemistry. Dideu Group offers this material in kilogram to metric ton quantities for pharmaceutical and fine chemical manufacturers worldwide.

Key Attributes

Key Highlights

• HIGH ASSAY: Not less than 99.0% by HPLC, with batch-specific assay results released on the certificate of analysis.
• PROVEN ROUTE INTERMEDIATE: Established building block for the pyrazole benzenesulfonamide chemistry behind celecoxib and related COX-2 inhibitor programs.
• FULL CHARACTERIZATION: Structure confirmed by IR and 1H NMR; identity and purity data supplied with every consignment.
• LOW ENTRY QUANTITY: Minimum order of 1 kg, so process development, route screening and pilot batches can start without a bulk commitment.
• SCALE-UP READY: Supply available from 1 kg laboratory quantities through 25 kg drums up to metric ton industrial volumes.
• FAST TURNAROUND: Orders shipped within 2 weeks, with flexible dispatch by air or by sea according to order size and destination.
• CONSISTENT BATCH QUALITY: Controlled crystallization and drying give uniform particle appearance and stable assay from lot to lot.
• TECHNICAL SUPPORT: Dideu Group answers specification, documentation and packaging questions directly, without intermediate resellers.

Product Description

4-Hydrazinylbenzenesulfonamide hydrochloride is the hydrochloride salt of 4-hydrazinobenzenesulfonamide, a bifunctional aromatic intermediate carrying both a hydrazine group and a sulfonamide group on the same benzene ring. This combination makes it a versatile reagent for heterocyclic construction: the hydrazine nitrogen condenses readily with 1,3-dicarbonyl compounds, beta-keto esters and chalcones to form pyrazole and pyrazoline rings, while the sulfonamide function is retained in the final molecule as the pharmacophoric substituent. The material is supplied as a white to light yellow crystalline powder with an assay of not less than 99.0% by HPLC.

The hydrochloride salt form is preferred in industrial practice because it gives better defined crystallinity, easier filtration and more reproducible stoichiometry than the free base. Typical physical constants are a melting point of 149-152 C and a density of 1.644 g/cm3 at 20 C. The product is soluble in water and slightly soluble in methanol on heating, which supports both aqueous and alcoholic reaction media. As a hygroscopic solid, it is packed in moisture-barrier inner liners inside fiber drums and should be kept sealed between uses.

Dideu Group supplies 4-hydrazinylbenzenesulfonamide hydrochloride from 1 kg minimum order through to metric ton scale, with a standard lead time of within 2 weeks from order confirmation. Each shipment is accompanied by a certificate of analysis covering assay, appearance and identification. Technical data sheets and additional test items can be arranged on request for customers running qualification or validation programs.

Applications

Pharmaceutical Intermediates

The principal industrial use of this material is as the key hydrazine component in the manufacture of celecoxib, a widely prescribed selective COX-2 inhibitor. Condensation with the corresponding 1,3-dicarbonyl or enone partner builds the pyrazole core while retaining the benzenesulfonamide group, which is the structural feature responsible for COX-2 selectivity in this drug class.

Medicinal Chemistry and Analog Programs

Beyond the commercial celecoxib route, the compound is a standard starting material for libraries of N-arylpyrazole and pyrazoline sulfonamides studied as anti-inflammatory, antimicrobial and antiproliferative agents. Its predictable reactivity makes it a frequent choice in structure-activity relationship work on benzenesulfonamide scaffolds.

Agrochemical Synthesis

The hydrazine and sulfonamide functionality is also used in the synthesis of sulfonyl-containing agrochemical actives and heterocyclic crop protection intermediates, where the aromatic sulfonamide group contributes to target binding and to the physical properties of the final formulation.

Dyestuffs and Organic Intermediates

As an aromatic hydrazine derivative, it serves as an intermediate in specialty dyestuff and organic synthesis routes that require a diazo-capable or hydrazono-forming aromatic amine precursor carrying a solubilizing sulfonamide group.

Analytical and Reference Use

The substance is used as a reference material for impurity profiling and method development in analytical laboratories working on pyrazole sulfonamide active substances, supporting chromatographic identification and quantification work.

Specifications

A batch-specific certificate of analysis is issued with each shipment. Additional test items can be agreed on request for qualification programs.

Packaging and Shipping

Storage Recommendations

• Keep containers tightly closed in a cool, dry and well-ventilated place.
• Protect from light and from moisture; the material is hygroscopic.
• For extended storage, keep under nitrogen or argon and reseal promptly after each use.
• Store away from sources of heat and avoid temperature fluctuation during warehousing.

Mode of Transport: by air or by sea, selected according to order size, destination and customer preference.

Lead Time: within 2 weeks from order confirmation.

Minimum Order Quantity: 1 kg.

Company Profile

Dideu Group is a professional supplier of fine chemicals and specialty chemicals, serving customers in global markets with a full range of products from lab-scale reagents to industrial quantities. Our portfolio covers pharmaceutical intermediates, agrochemical intermediates and custom organic building blocks for research and manufacturing users.

We work directly with production partners and maintain documented quality control on every lot, so customers receive consistent material together with the analytical data needed for incoming inspection. Orders are handled by an experienced export team that manages documentation, packing and shipment coordination from inquiry through delivery. Whether the requirement is a single kilogram for route development or recurring metric ton volumes for commercial production, Dideu Group supports the program with reliable supply and responsive technical communication.

FAQ

1. What is the minimum order quantity?

The minimum order is 1 kg. Larger industrial orders are supplied in 5 kg and 25 kg fiber drums, and metric ton quantities can be arranged for recurring production needs.

2. What is the lead time?

Dideu Group ships orders within 2 weeks from order confirmation. For metric ton volumes or special documentation requirements, the exact schedule is confirmed at the quotation stage.

3. What packaging options do you offer?

Standard packing is a 1 kg HDPE bottle for small quantities and 5 kg or 25 kg fiber drums with a moisture-barrier inner liner for bulk. Drums are palletized for container loading. Alternative packing can be discussed on request.

4. What payment terms do you accept?

We accept T/T and L/C. The specific terms are agreed in the proforma invoice according to order value and destination.

5. Do you provide a COA and technical documents?

Yes. A batch-specific certificate of analysis covering assay, appearance and identification is issued with each shipment. Technical data sheets and supporting analytical data are available on request.

6. How do you ship the goods?

Shipments move by air or by sea depending on order size and delivery urgency. Small kilogram quantities are typically dispatched by air for speed, while drum and pallet volumes go by sea for cost efficiency.