5-Bromo-1H-pyrimidin-4-one CAS 19808-30-1 98% High Purity Brominated Pyrimidinone Intermediate for Pharmaceutical Synthesis
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Keywords: 5-bromo-1H-pyrimidin-4-one, CAS 19808-30-1, bromopyrimidinone, pyrimidin-4-one building block, pharmaceutical intermediate
Product Overview
5-Bromo-1H-pyrimidin-4-one is a brominated pyrimidinone building block supplied as an off-white to light yellow crystalline solid. The bromine atom at the C5 position makes it a practical starting material for palladium catalysed carbon to carbon bond forming reactions, and the pyrimidin-4-one core is a recurring scaffold in medicinal chemistry and crop protection programs. Dideu Group supplies this intermediate from gram quantities for route scouting up to kilogram quantities for development and scale-up.
Key Attributes
| CAS No. |
19808-30-1 |
| Product Name |
5-Bromo-1H-pyrimidin-4-one |
| IUPAC Name |
5-bromopyrimidin-4(1H)-one |
| Molecular Formula |
C4H3BrN2O |
| Molecular Weight |
174.98 g/mol |
| EINECS / EC No. |
243-334-4 |
| Appearance |
Off-white to light yellow crystalline powder or solid |
| Assay / Purity |
98.0% (97.0% grade also available) |
| Melting Point |
198 - 200 C |
| Boiling Point |
241 C at 760 mmHg |
| Density |
Approx. 2.0 g/cm3 |
| Solubility |
Slightly soluble in water; soluble in common polar organic solvents |
| Chemical Category |
Nitrogen heterocyclic compound, bromopyrimidine, pyrimidinone intermediate |
| Storage Condition |
Store in a tightly closed container, in a cool, dry and well-ventilated place at room temperature, protected from light and moisture |
Key Highlights
- HIGH PURITY: 98.0% assay as standard, with a 97.0% grade available for cost-sensitive development work.
- READY FOR CROSS-COUPLING: The C5 bromine is a reliable leaving group for Suzuki, Sonogashira and Buchwald type carbon to carbon bond formation.
- FLEXIBLE QUANTITY: Pack sizes from 100 g up to 25 kg, with a minimum order quantity of 1 kg.
- FAST LEAD TIME: Orders are normally shipped within 2 weeks after confirmation.
- DOCUMENTED QUALITY: Certificate of Analysis and technical documents are issued with every batch.
- DIRECT SUPPLY: Sourced through Dideu Group, giving stable availability and consistent specification from batch to batch.
Product Description
5-Bromo-1H-pyrimidin-4-one (CAS 19808-30-1, molecular formula C4H3BrN2O, molecular weight 174.98 g/mol) is a halogenated pyrimidin-4-one supplied as an off-white to light yellow crystalline solid. It belongs to the bromopyrimidine family of nitrogen heterocyclic compounds and is widely handled as a pharmaceutical and agrochemical intermediate. The material has a melting point of 198 - 200 C and is slightly soluble in water.
The value of this compound lies in its two functional handles. The bromine at the C5 position allows transition metal catalysed arylation, alkynylation and amination, while the pyrimidin-4-one ring can be further derivatised at nitrogen or converted into chloro and amino pyrimidine forms. This makes it a practical entry point into substituted pyrimidinone libraries used in structure activity relationship studies.
Dideu Group supplies 5-bromo-1H-pyrimidin-4-one in pack sizes from 100 g to 25 kg, with a minimum order quantity of 1 kg and a lead time within 2 weeks. Each batch is shipped with a Certificate of Analysis covering assay and appearance, and additional analytical data can be provided on request. Technical support is available for specification alignment before order confirmation.
Applications
- Pharmaceutical intermediates: Used as a starting material in the synthesis of substituted pyrimidinone compounds, including kinase inhibitor scaffolds reported in the patent and medicinal chemistry literature.
- Cross-coupling building block: Serves as a coupling partner in palladium catalysed reactions such as Suzuki-Miyaura and Sonogashira chemistry for introducing aryl and alkynyl groups at the C5 position.
- Crop protection chemistry: Used as an intermediate in pyrimidine chemistry for plant protection active substances.
- Research and development: May be used in the preparation of modified nucleoside analogues and heterocyclic reference compounds for academic and industrial research.
- Further derivatisation: May be used as a precursor to halogen exchanged and N-substituted pyrimidin-4-one derivatives in multi-step synthesis programs.
Note: The pharmaceutical, cross-coupling and crop protection uses are supported by published synthetic literature. The research reagent and derivatisation items above are inferred from the molecular structure and the behaviour of related bromopyrimidines, and should be validated against your own process requirements.
Specifications
| Item |
Specification |
Typical Value |
| Assay |
>= 98.0% |
98.0% |
| Appearance |
Off-white to light yellow crystalline solid |
Complies |
| Melting Point |
198 - 200 C |
Complies |
| Solubility in Water |
Slightly soluble |
Complies |
Additional test items and limits can be aligned with your incoming quality specification. Batch specific values are stated on the Certificate of Analysis accompanying each shipment.
Packaging and Shipping
| Packaging Type |
Standard Sizes |
| Sealed inner bag in carton or fiber drum |
100 g, 500 g, 1 kg |
| Fiber drum with double inner liner |
5 kg, 25 kg |
Storage advice:
- Keep the container tightly closed after each use.
- Store in a cool, dry and well-ventilated place at room temperature.
- Protect from direct sunlight and from moisture.
Minimum order quantity is 1 kg. Lead time is within 2 weeks after order confirmation. Goods are shipped by air or by sea according to order size and destination, and packing is arranged to keep the material dry and sealed during transit.
Company Profile
Dideu Group is a professional supplier of fine chemicals and specialty chemicals, serving customers in global markets with a full range of products from lab-scale reagents to industrial quantities. Our portfolio covers heterocyclic intermediates, brominated and halogenated building blocks, and custom synthesis intermediates for the pharmaceutical, agrochemical and research sectors.
We work with qualified manufacturing partners and apply incoming and outgoing quality checks so that specification, assay and documentation stay consistent from batch to batch. Every shipment is accompanied by a Certificate of Analysis, and technical documents are provided on request. Our sales and technical team responds quickly to enquiries and supports specification alignment, packaging requirements and delivery scheduling for customers in global markets.
FAQ
1. What is the minimum order quantity?
The minimum order quantity for 5-bromo-1H-pyrimidin-4-one is 1 kg. Smaller pack sizes of 100 g and 500 g are available for evaluation and route development, subject to confirmation by Dideu Group.
2. What is the lead time?
Orders are normally ready for shipment within 2 weeks after confirmation. For larger quantities the exact schedule is confirmed when the order is placed.
3. What packaging options do you offer?
Standard pack sizes are 100 g, 500 g, 1 kg, 5 kg and 25 kg. Solid material is packed in a sealed inner bag placed in a carton or fiber drum. Customised packaging can be arranged on request.
4. What payment terms do you accept?
Dideu Group accepts T/T and L/C. The specific terms are agreed during order confirmation.
5. Do you provide COA and technical documents?
Yes. A Certificate of Analysis covering assay, appearance and melting point is issued with every batch, and further technical documents can be provided on request.
6. How do you ship the goods?
Shipments are arranged by air or by sea depending on order size and destination. Packing is sealed and moisture protected for the transit period.
India
