High- Quality Allopregnanolone CAS 516-54-1 Raw Powder Pharmaceutical Intermediate
COA TDS 8 Inquiries
516-54-1
Pharmaceutical Grade
99.6%
1
Million
25kg/Cardboard Drum
Yes
2026-11-12
Avanafil,Tirzepatide,Semaglutide,Pregabalin,Nootropics,MT2
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Product Details
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceAllopregnanolone is a progesterone metabolite. Allopregnanolone is an allosteric modulator of the GABA receptor.
Solid
Brexanolone is a 3-hydroxy-5alpha-pregnan-20-one in which the hydroxy group at position 3 has alpha-configuration. It is a metabolite of the sex hormone progesterone and used for the treatment of postpartum depression in women. It has a role as a human metabolite, an antidepressant, a GABA modulator, an intravenous anaesthetic and a sedative.|Brexanolone is a DEA Schedule IV controlled substance. Substances in the DEA Schedule IV have a low potential for abuse relative to substances in Schedule III.|As of March 2019, brexanolone - developed and made available commercially by Sage Therapeutics Inc. as the brand name product Zulresso - is the first drug to have ever been approved by the US FDA specifically for the treatment of postpartum depression (PPD) in adult females. Since PPD, like various other types of depression, is characterized by feelings of sadness, worthlessness or guilt, cognitive impairment, and/or possibly suicidal ideation, it is considered a life-threatening condition. Studies have consequently found that PPD can genuinely have profound negative effects on the maternal-infant bond and later infant development. The development and availability of brexanolone for the treatment of PPD in adult females subsequently provides a new and promising therapy where few existed before. In particular, the use of brexanolone in treating PPD is surrounded with promise because it acts in part as a synthetic supplement for possible deficiencies in endogenous brexanolone (allopregnanolone) in postpartum women susceptible to PPD whereas many commonly used anti-depressive medications elicit actions that may modulate the presence and activity of substances like serotonin, norepinephrine, and/or monoamine oxidase but do not mediate activities directly associated with PPD like natural fluctuations in the levels of endogenous neuroactive steroids like allopregnanolone. And finally, although brexanolone may also be undergoing clinical trials to investigate its abilities to treat super-refractory status epilepticus, it appears that some such studies have failed to meet primary endpoints that compare success in the weaning of third-line agents and resolution of potentially life-threatening status epilepticus with brexanolone vs. placebo when added to standard-of-care.|Brexanolone is a unique, intravenously administered, neuroactive steroidal antidepressant used in the therapy of moderate-to-severe postpartum depression. In prelicensure clinical trials, brexanolone therapy was not associated with an increased rate of serum aminotransferase elevations, and it has not been linked to instances of clinically apparent acute liver injury.|A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.Research & Reference NoteHigh- Quality Allopregnanolone CAS 516-54-1 Raw Powder Pharmaceutical Intermediate is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Authoritative sourcesDisclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals
CertificatesBasic Info-
Product Name:
3α-Hydroxy-5α-pregnan-20-one
Other Name:Pregnan-20-one,3-hydroxy-,(3α,5α)-;5α-Pregnan-20-one,3α-hydroxy-;(3α,5α)-3-Hydroxypregnan-20-one;Allopregnan-3α-ol-20-one;3α-Hydroxy-5α-pregnan-20-one;3α-Hydroxy-5α-pregnane-20-one;3α,5α-Pregnanolone;3α-Hydroxy-5α-dihydroprogesterone;3α,5α-Tetrahydroprogesterone;Allotetrahydroprogesterone;5α-Pregnane-3α-ol-20-one;(3α)-Allopregnanolone;(+)-3α-Hydroxy-5α-pregnan-20-one;Allopregnanolone;3α,5α-THP;5α-Pregnan-3α-ol-20-one;SAGE 547;Allopregnanolone (SAGE-547);Brexanolone;Zulresso
CAS No.:516-54-1
Molecular Formula:C21H34O2
InChIKeys:InChIKey=AURFZBICLPNKBZ-SYBPFIFISA-N
Molecular Weight:318.49
Exact Mass:318.49
UNII:S39XZ5QV8Y
DEA Code Number:2400
Categories:
Characteristics-
PSA:
37.3
XLogP3:4.89
Appearance:white
Density:1.1±0.1 g/cm3
Melting Point:177 °C
Boiling Point:431.2±18.0 °C at 760 mmHg
Flash Point:183.9±13.8 °C
Refractive Index:1.524
Water Solubility:chloroform: 20 mg/mL, clear, colorless
Storage Conditions:Store at RT
Specific rotation:D +87.7° (abs alc)
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Avanafil,Tirzepatide,Semaglutide,Pregabalin,Nootropics,MT2
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Location:
Room 1-2208, Lianhecaifu Square, No2177, Tianchen Road, Gaoxin District, Jinan City, Shandong Province, China
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Payment Terms:
L/C,100% TT in advance
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Average lead Time:
3 days
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2012
Company Certificates-
![Jinan Million Pharmaceutical Co., Ltdbusiness license]( "business license")
business license
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Inquiry History8 Inquiries
Country Product Purchase Quantity Date Posted 
Singapore
Allopregnanolone
100 G Oct 21, 2024 
Australia
Allopregnanolone
1 KG Feb 26, 2026
Australia
Allopregnanolone
5 G Jan 13, 2025 
United States
Allopragnanolone
250 G Sep 7, 2026 
France
Allopregnanolone
100 MG Jul 25, 2025 
Georgia
allopregnenolone
10 MG Feb 21, 2025
Georgia
Allopregnenolone
1 KG Feb 19, 2025 
Chile
Allopregnanolone
20 G Aug 17, 2024 Post an enquiry for this product
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