High Quality Erdafitinib 99% powder SAG 21k -Shaanxi Dideu Medichem Co.Ltd
TDS 75 Inquiries
946002-48-8
Chemical Grade
99%
SHANGHAI
Dideu
1g/bottle
Yes
2030-01-01
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Product Details
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Seller Information
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Inquiry History
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DescriptionCertificatesBasic Info
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Product Name:
3-chloro-4,7-difluoro-N-(2-Methoxy-5-(pyridin-4-yl)benzyl)-N-(4-(MethylaMino)cyclohexyl)benzo[b]thiophene-2-carboxaMide
Other Name:SAG 21k;3-chloro-4,7-difluoro-N-[(2-methoxy-5-pyridin-4-ylphenyl)methyl]-N-[4-(methylamino)cyclohexyl]-1-benzothiophene-2-carboxamide;3-Chloro-4,7-difluoro-N-[[2-methoxy-5-(4-pyridinyl)phenyl]methyl]-N-trans-4-(methylamino)cyclohexyl]benzo[b]thiophene-2-carboxamide;3-chloro-4,7-difluoro-N-{[2-methoxy-5-(pyridin-4-yl)phenyl]methyl}-N-[trans-4-(methylamino)cyclohexyl]-1-benzothiophene-2-carboxamide;SCHEMBL12678477;SCHEMBL12678631;SCHEMBL12678943;SCHEMBL14202180;SCHEMBL20535825;AKOS030210943
CAS No.:946002-48-8
Molecular Formula:C29H28ClF2N3O2S
InChIKeys:YVIFQUJDZSAFKG-UHFFFAOYSA-N
Molecular Weight:556.0663264
Exact Mass:555.156
EC Number:-0
Categories:
Characteristics-
PSA:
82.7
XLogP3:6.5
Research-
Class:
Pan-FGFR tyrosine kinase inhibitor (FGFR1-4); antineoplastic (ATC L01EN01)
Status:Approved (FDA accelerated approval 2019-04-12; converted to regular approval 2024-01-19; EMA approval 2024-08)
Mechanism:Erdafitinib is an orally bioavailable, functionally selective small-molecule inhibitor of fibroblast growth factor receptors 1-4 (FGFR1-4). It inhibits FGFR tyrosine kinase activity (IC50 1.2-5.7 nM), blocking downstream RAS-MAPK/ERK and PI3K-AKT signaling that drives proliferation and survival of tumor cells harboring activating FGFR alterations (mutations, amplifications, or fusions). Rapid lysosomal uptake contributes to prolonged inhibition of FGFR signaling.
EC50 (Fgfr1 Ic50):1.2 nM
EC50 (Fgfr3 Ic50):3.0 nM
EC50 (Fgfr2 Ic50):2.5 nM
EC50 (Fgfr4 Ic50):5.7 nM
EC50 (Vegfr2 Ic50):36.8 nM (approximately 30-fold selectivity vs FGFR1)
Source:Perera TPS, et al. Mol Cancer Ther. 2017;16(6):1010-1020.DOI
Clinical Development:FDA:Balversa (approved 2019-04-12)
References-
ChEMBL:DrugBank:KEGG DRUG:PubChem:Literature:
FDA: Approval announcement 2024-01-19; FDA: BALVERSA label (NDA 212018, BLC2001); NEJM: Loriot et al. (2023) — THOR Cohort 1; NEJM: Loriot et al. (2019) — BLC2001; Mol Cancer Ther: Perera et al. (2017) — discovery pharmacology
Disclaimer:Erdafitinib (Balversa) is a prescription medicine approved by the US FDA and the EMA for specific oncology indications. ECHEMI lists this product for industrial sourcing and supply-chain reference only. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or a substitute for approved therapy. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Location:
https://www.dideu.com/en/
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7 days
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Total Annual Revenue:
Above $100 million
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Total Employees:
Above 1000
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Year of Establishment:
2016
Company Certificates-
ISO Certificate
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REACH
">Company Profile -
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Inquiry History75 Inquiries
Country Product Purchase Quantity Date Posted
Philippines
Custom Chemical Pure 98% HPLC SAG21k SAG 21k Raw Powder CAS 946002-48-8
1 G Sep 6, 2026
France
3-chloro-4,7-difluoro-N-(2-Methoxy-5-(pyridin-4-yl)benzyl)-N-(4-(MethylaMino)cyclohexyl)benzo[b]thiophene-2-carboxaMide
70 MG Oct 15, 2026
United States
3-chloro-4,7-difluoro-N-(2-Methoxy-5-(pyridin-4-yl)benzyl)-N-(4-(MethylaMino)cyclohexyl)benzo[b]thiophene-2-carboxaMide
1 MT Oct 18, 2026
Italy
Sag21k
500 MG Oct 16, 2026
United States
SAG21K
1 G Oct 16, 2026
United States
3-chloro-4,7-difluoro-N-(2-Methoxy-5-(pyridin-4-yl)benzyl)-N-(4-(MethylaMino)cyclohexyl)benzo[b]thiophene-2-carboxaMide
1000 MG Oct 11, 2026
United States
3-chloro-4,7-difluoro-N-(2-Methoxy-5-(pyridin-4-yl)benzyl)-N-(4-(MethylaMino)cyclohexyl)benzo[b]thiophene-2-carboxaMide
1 G Oct 8, 2026
Italy
sag21k
100 MG Oct 7, 2026
United States
3-chloro-4,7-difluoro-N-(2-Methoxy-5-(pyridin-4-yl)benzyl)-N-(4-(MethylaMino)cyclohexyl)benzo[b]thiophene-2-carboxaMide
150 MG Oct 4, 2026
Poland
3-chloro-4,7-difluoro-N-(2-Methoxy-5-(pyridin-4-yl)benzyl)-N-(4-(MethylaMino)cyclohexyl)benzo[b]thiophene-2-carboxaMide
100 G Oct 2, 2026
Germany
3-chloro-4,7-difluoro-N-(2-Methoxy-5-(pyridin-4-yl)benzyl)-N-(4-(MethylaMino)cyclohexyl)benzo[b]thiophene-2-carboxaMide
500 MG Sep 21, 2026
Germany
3-chloro-4,7-difluoro-N-(2-Methoxy-5-(pyridin-4-yl)benzyl)-N-(4-(MethylaMino)cyclohexyl)benzo[b]thiophene-2-carboxaMide
1 G Sep 20, 2026
United Kingdom
SAG21k
400 MG Sep 13, 2026
United States
sag21k
1 MT Sep 9, 2026
Canada
SAG21k
400 MG Sep 9, 2026
United States
Sag21k
1 G Aug 30, 2026
United States
Sag21k
230 MG Aug 25, 2026
Poland
SAG21K
2 G Aug 23, 2026
United States
SAG21K Powder
20 G Aug 23, 2026
United States
SAG 21K
1 G Aug 23, 2026 Post an enquiry for this product
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