Product Overview

4-Bromo-2-chlorobenzoic acid is an organic compound with the molecular formula C₇H₄BrClO₂ and molecular weight of 235.46 g/mol. This white to off-white crystalline solid is a valuable intermediate in pharmaceutical, agrochemical, and organic synthesis research. The compound features a bromine atom at the 4-position, a chlorine atom at the 2-position, and a carboxylic acid group on the benzene ring.

Synthetic Process

• Bromination: 2-Chlorobenzoic acid is brominated at the 4-position using elemental bromine or NBS in the presence of a catalyst

• Purification: The crude product is purified by recrystallization from suitable solvents

• Drying: The purified product is dried under vacuum

Mechanism of Action

• Carboxylic Acid Reactivity: The acid group can be converted to esters, amides, and acid chlorides

• Cross-Coupling Substrate: The aryl bromide enables Suzuki-Miyaura and other coupling reactions

• Halogen Differentiation: The presence of both bromine and chlorine allows for selective functionalization

Research Applications & Market Significance

• Pharmaceutical Research: Building block for drug discovery programs

• Agrochemical Synthesis: Intermediate for herbicides and fungicides

• Organic Synthesis: Versatile intermediate for functionalized benzoic acid derivatives

• Material Science: Used in the preparation of specialty polymers

Quality Specifications

• Purity: ≥98.0% determined by HPLC

• Melting point: 168-171°C

• Loss on drying: ≤0.5%

• Residue on ignition: ≤0.1%

• Storage: 2-8°C, sealed, protected from light

• Stable for 36 months when properly stored

Packaging & Shipping

• Research quantities: 25g, 100g amber glass bottles

• Bulk quantities: 500g, 1kg amber glass bottles

• Shipped at ambient temperature