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Home > Encyclopedia > Bivalirudin

Bivalirudin

Bivalirudin structure
  • CAS No:

    128270-60-0

  • Formula:

    C98H138N24O33

  • China Export:

    From 2018.11 to 2019.11, total export volume of Bivalirudin from China was 13,855,645KG while total export value was $145,351,813. The biggest proportion of exporting volume in the last 12 months was 13.76% in 2019.03.

  • Categories:

    Biochemical Engineering  >  Polypeptide

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Description

Bivalirudin Trifluoroacetate is a synthetic 20 residue peptide which reversibly inhibits thrombin.IC50 Value:Target: thrombinin vitro: Eptifibatide (8 mg/mL) added together with a low (70 ng/mL) concentration of bivalirudin (a direct thrombin inhibitor) effectively (approximately 90%) reduced platelet aggregation induced by thrombin (0.2 U/mL) [1]. In thrombin generation assay (TGA), bivalirudin had no effect on these parameters up to 10 μmol/l [2]. Bivalirudin-facilitated binding of MPO

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Basic Attributes

  • 128270-60-0

  • C98H138N24O33

  • 218029

  • 2179.989

  • 902

  • -2.24

  • OIRCOABEOLEUMC-GEJPAHFPSA-N

  • 35

  • 28

  • 67

Characteristics

  • white to off-white

  • 1.5±0.1 g/cm3

  • 1.675

  • -20°C

Safety Information

  • 2942000000

Usage

Bivalirudin (Angiomax or Angiox, manufactured by The Medicines Company) is a specific and reversible direct thrombin inhibitor (DTI).Chemically, it is a synthetic congener of the naturally occurring drug hirudin (found in the saliva of the medicinal leech Hirudo medicinalis).Bivalirudin is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. Bivalirudin is a short, synthetic peptide that is potent, highly specific, and a reversible inhibitor of thrombin. It inhibits both circulating and clot-bound thrombin, while also inhibiting thrombin-mediated platelet activation and aggregation. Bivalirudin has a quick onset of action and a short half-life. It does not bind to plasma proteins (other than thrombin) or to red blood cells. Therefore, it has a predictable antithrombotic response. There is no risk for Heparin Induced Thrombocytopenia/Heparin Induced Thrombosis-Thrombocytopenia Syndrome (HIT/HITTS). It does not require a binding cofactor such as antithrombin and does not activate platelets. These characteristics make bivalirudin an ideal alternative to heparin.Bivalirudin clinical studies demonstrated consistent positive outcomes in patients with stable angina, unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) undergoing PCI in 7 major randomized trials. Patients receiving bivalirudin had fewer adverse events compared to patients that received heparin.

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China Bivalirudin Export Data

Data referenced from General Administration of Customs,P.R.China

2018.11-2019.11 China - America  Bivalirudin Export Data

From 2018.11 to 2019.11, total export volume of Bivalirudin from China to America was 480,006KG while total export value was $45,391,064. The biggest proportion of exporting volume in the last 12 months was 17.96% in 2019.07.

2018.11-2019.11 China Bivalirudin Export Data

From 2018.11 to 2019.11, total export volume of Bivalirudin from China was 13,855,645KG while total export value was $145,351,813. The biggest proportion of exporting volume in the last 12 months was 13.76% in 2019.03.

2018.11-2019.11 TOP10 Purchasing Countries' Export Data of Chinese Bivalirudin

From 2018.11 to 2019.11, China has exported Bivalirudin to 100 countries in total. Country ranks by import volume from high to low is Japan, Turkey, India, Korea, Philippines, Thailand, Vietnam, Taiwan, Indonesia, America. The highest export volume was China to Japan, accounting for 10.37% of the total volume of China.

Check Export Data for More Purchasing Countries

Purchasing Country Export Volume(KG) Export Percentage Export Value($)

Japan

2,559,315

10.37%

27,953,840

Turkey

1,340,775

5.43%

570,748

India

1,288,780

5.22%

11,328,226

Korea

1,168,561

4.74%

13,005,027

Philippines

684,726

2.78%

695,551

Thailand

627,389

2.54%

1,366,640

Vietnam

590,465

2.39%

1,602,218

Taiwan

547,963

2.22%

6,160,199

Indonesia

522,371

2.12%

1,131,168

America

480,006

1.95%

45,391,064

Iraq

366,400

1.48%

881,824

Germany

323,013

1.31%

10,488,558

Sri Lanka

280,420

1.14%

265,106

Malaysia

274,549

1.11%

403,684

Netherlands

247,250

1.00%

1,659,181

Russia

224,861

0.91%

521,649

Ivory Coast

210,000

0.85%

10,500

Chad

208,000

0.84%

516,420

Belgium

160,347

0.65%

972,413

Spain

156,857

0.64%

5,486,523

Kuwait

140,000

0.57%

274,500

Lebanon

117,387

0.48%

145,647

Cameroon

115,200

0.47%

905,514

Ghana

107,960

0.44%

85,026

United Kingdom

92,018

0.37%

3,168,668

Honduras

90,000

0.36%

4,900

Iran

77,101

0.31%

355,567

Kazakstan

75,870

0.31%

160,920

Syria

64,800

0.26%

83,067

Mongolia

59,002

0.24%

106,613

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