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Linoleic acid

Linoleic acid structure

CAS No:
60-33-3
Formula:
C18H32O2
Chemical Name:
Linoleic acid
Synonyms:
9,12-Octadecadienoic acid (9Z,12Z)-;Linoleic acid;9,12-Octadecadienoic acid (Z,Z)-;(9Z,12Z)-9,12-Octadecadienoic acid;9Z,12Z-Linoleic acid;cis-9,cis-12-Octadecadienoic acid;Polylin 515;cis,cis-Linoleic acid;Unifac 6550;Linolic acid;9,12-Octadecadienoic acid,(Z,Z)-;(Z,Z)-9,12-Octadecadienoic acid;cis-Δ9,12-Octadecadienoic acid;C18:2;α-Linoleic acid;9-cis,12-cis-Linoleic acid;all-cis-9,12-Octadecadienoic acid;Emersol 315;Extra Linoleic 90;9Z,12Z-Octadecadienoic acid;Ronacare ASC 3;CA 1726;(9Z,12Z)-Octadec-9,12-dienoic acid;9,12-Octadecanoic acid;949900-18-9
Categories:
Cosmetic Ingredient > Antistatic

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Description

Liquid at room temperature, colorless Linoleic acid occurs as a colorless to light-yellow-colored oil.

Linoleic acid Basic Attributes

Molecular Weight：

280.45

Exact Mass：

280.45

BRN：

1727101

EC Number：

200-470-9

HScode：

29161500

Characteristics

PSA：

37.3

XLogP3：

6.8

Appearance：

Clear yellow liquid

Density：

0.9022 g/cm³ @ Temp: 20 °C

Melting Point：

-12 °C

Boiling Point：

365.2 °C

Flash Point：

>230 °F

Refractive Index：

n20/D 1.466(lit.)

Water Solubility：

H2O: INsoluble ;NaOH: soluble 1M

Storage Conditions：

2-8°C

Vapor Pressure：

8.68X10-7 mm Hg at 25 deg C

Toxicity：

LD50 oral in mouse: > 50gm/kg

Explosive limit：

Combustible

Safety Information

Transport codes：

UN1170 - class 3 - PG 2 - Ethanol

wgk germany：

hazard class code：

36-36/37/38

safety instructions：

26-24/25-36-37/39

RTECS Number：

RF9990000

Marks：

Stability/Shelf Life：

Stability Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P261, P264, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

Linoleic acid Use and Manufacturing

Methods of Manufacturing

It is obtained by hydrolysis and fractional distillation of linseed oil.

Uses

paint. coating. Emulsifier. Drier.

Computed Properties

Molecular Weight:280.4
XLogP3:6.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:14
Exact Mass:280.240230259
Monoisotopic Mass:280.240230259
Topological Polar Surface Area:37.3
Heavy Atom Count:20
Complexity:267
Defined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It can combine with cholesterol to form esters, and may promote its degradation into bile acid for excretion, which has the effect of lowering blood cholesterol, reducing the content of triglycerides, low-density lipoproteins and very low-density lipoproteins, and increasing the content of high-density lipoproteins. It changes the distribution of cholesterol in the body, reduces the deposition of lipids in the blood vessel wall, and can change the composition and structure of lipoproteins, increase the fluidity of cell membranes and lipoproteins, and improve or protect the function of blood vessel walls.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound three-dimensional linoleic acid capsules Ⅰ
Ingredients	This product is a compound preparation, and its components are: each capsule contains 0.35g linoleic acid, 2mg vitamin B6, 25mg vitamin C, 1.67mg vitamin E, 10mg inositol, 24mg soybean lecithin, and 10mg methyl hesperidin.
Indication	1. Oral administration of large doses of vitamin C (more than 10g per day) can interfere with the anticoagulant effect of anticoagulants. 2. Combined use with barbiturates or primidone can increase the excretion of vitamin C. 3. Sodium cellulose phosphate can promote the metabolism of vitamin C into oxalate. 4. Long-term and large-scale use of vitamin C can interfere with the effect of disulfiram on ethanol. 5. Salicylic acid can increase the excretion of vitamin C. 6. Chloramphenicol, cycloserine, ethionamide, hydralazine hydrochloride, immunosuppressive drugs including adrenocortical hormones, cyclophosphamide, cyclosporine, isoniazid, penicillamine, etc. can antagonize vitamin B6 or increase the excretion of vitamin B6 through the kidneys, which can cause anemia or peripheral neuritis. 7. Levodopa combined with a small dose of vitamin B6 (5mg per day) can antagonize the anti-tremor effect of levodopa. But it has no effect on carbidopa.
Specifications	Compound
Manufacturer	Dalian Aquatic Pharmaceutical Co., Ltd.

Compound three-dimensional linoleic acid capsules Ⅰ
Ingredients	This product is a compound preparation, and its components are: each capsule contains 0.35g linoleic acid, 2mg vitamin B6, 25mg vitamin C, 1.67mg vitamin E, 10mg inositol, 24mg soybean lecithin, and 10mg methyl hesperidin.
Indication	1. Oral administration of large doses of vitamin C (more than 10g per day) can interfere with the anticoagulant effect of anticoagulants. 2. Combined use with barbiturates or primidone can increase the excretion of vitamin C. 3. Sodium cellulose phosphate can promote the metabolism of vitamin C into oxalate. 4. Long-term and large-scale use of vitamin C can interfere with the effect of disulfiram on ethanol. 5. Salicylic acid can increase the excretion of vitamin C. 6. Chloramphenicol, cycloserine, ethionamide, hydralazine hydrochloride, immunosuppressive drugs including adrenocortical hormones, cyclophosphamide, cyclosporine, isoniazid, penicillamine, etc. can antagonize vitamin B6 or increase the excretion of vitamin B6 through the kidneys, which can cause anemia or peripheral neuritis. 7. Levodopa combined with a small dose of vitamin B6 (5mg per day) can antagonize the anti-tremor effect of levodopa. But it has no effect on carbidopa.
Specifications	Compound
Manufacturer	Tianjin Jun'an Biopharmaceutical Co., Ltd.

Compound three-dimensional linoleic acid capsules Ⅰ
Ingredients	This product is a compound preparation, and its components are: each capsule contains 0.35g linoleic acid, 2mg vitamin B6, 25mg vitamin C, 1.67mg vitamin E, 10mg inositol, 24mg soybean lecithin, and 10mg methyl hesperidin.
Indication	1. Oral administration of large doses of vitamin C (more than 10g per day) can interfere with the anticoagulant effect of anticoagulants. 2. Combined use with barbiturates or primidone can increase the excretion of vitamin C. 3. Sodium cellulose phosphate can promote the metabolism of vitamin C into oxalate. 4. Long-term and large-scale use of vitamin C can interfere with the effect of disulfiram on ethanol. 5. Salicylic acid can increase the excretion of vitamin C. 6. Chloramphenicol, cycloserine, ethionamide, hydralazine hydrochloride, immunosuppressive drugs including adrenocortical hormones, cyclophosphamide, cyclosporine, isoniazid, penicillamine, etc. can antagonize vitamin B6 or increase the excretion of vitamin B6 through the kidneys, which can cause anemia or peripheral neuritis. 7. Levodopa combined with a small dose of vitamin B6 (5mg per day) can antagonize the anti-tremor effect of levodopa. But it has no effect on carbidopa.
Specifications	Compound
Manufacturer	Guangzhou Baiyunshan Xingqun Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Heilongjiang Hongrunyuan Pharmaceutical Co., Ltd.

China
Active
Shanghai Jinban Pharmaceutical Co., Ltd.

China
Active
Guangzhou Hanfang Pharmaceutical Company Limited

China
Active

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Guide of Linoleic acid

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

Linoleic acid

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