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Epirubicin hydrochloride

Epirubicin hydrochloride structure

CAS No:
56390-09-1
Formula:
C27H29NO11.ClH
Chemical Name:
Epirubicin hydrochloride
Synonyms:
5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,hydrochloride (1:1),(8S,10S)-;5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride,(8S-cis)-;5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride,(8S,10S)-;4′-epi-Adriamycin hydrochloride;4′-Epidoxorubicin hydrochloride;Epirubicin hydrochloride;Farmorubicin;Pharmorubicin;Epidoxorubicin hydrochloride;Ellence
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

Epirubicin (hydrochloride) is a semisynthetic L-arabino derivative of doxorubicin, and an antineoplastic agent by inhibiting Topoisomerase.

An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.

Epirubicin hydrochloride Basic Attributes

Molecular Weight：

579.9802

Exact Mass：

579.150757

EC Number：

260-145-2

NSC Number：

256942|123127

HScode：

2932999099

Characteristics

PSA：

206

XLogP3：

1.50360

Appearance：

red to deep red

Density：

1.61g/cm3

Melting Point：

185 °C (decomp)

Boiling Point：

810.3°C at 760 mmHg

Flash Point：

443.8℃

Refractive Index：

1.709

Water Solubility：

soluble in DMSO to 100mM, or in ethanol to 10mM

Storage Conditions：

Desiccate at +4°C

Specific rotation：

D20 +274° (c = 0.01 in methanol)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-63-62-46-40

safety instructions：

36/37/38-45-46

RTECS Number：

QI9295750

Marks：

Precautionary statement(s)：

P201-P280-P301 + P312 + P330-P308 + P313

Hazard Statements：

H302-H340-H350-H360

GHS Classification：

|Danger|H302 (99.21%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501|Aggregated GHS information provided by 127 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)|Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)

MeSH Entry Terms：

Adriablastin|4' Epi Adriamycin

Epirubicin hydrochloride Use and Manufacturing

Used as an antineoplastic

Computed Properties

Molecular Weight:580.0
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:5
Exact Mass:579.1507385
Monoisotopic Mass:579.1507385
Topological Polar Surface Area:206
Heavy Atom Count:40
Complexity:977
Defined Atom Stereocenter Count:2
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Epirubicin Hydrochloride

Epirubicin Hydrochloride for Injection
Specifications	10mg
Manufacturer	Beijing Xiehe Pharmaceutical Co., Ltd.

Epirubicin Hydrochloride Injection
Ingredients	Epirubicin Hydrochloride
Indication	1 Epirubicin can be used in combination with other anti-tumor drugs, but the dosage of epirubicin should be reduced. When used in combination, they should not be used in the same syringe. 2 Epirubicin should not be mixed with heparin for injection, because the two are chemically incompatible and precipitation reactions will occur at a certain concentration.
Specifications	25 ml: 50 mg

See More Related Drugs

Registered Holders

DZD (HEZE) PHARMACEUTICAL CO LTD

United States
Active
Synbias Pharma.Ltd.

Japan
Active
Gemini PharmChem Mannheim GmbH

Germany
Active

See More Registered Holders

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