(11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one
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![(11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/cd90cd32dddf46ac9205d1a836716927.png "(11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one")
(11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one
structure -
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CAS No:
120786-18-7
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Formula:
C15H18N2O
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Chemical Name:
(11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one
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Synonyms:
5,9-Methanocycloocta[b]pyridin-2(1H)-one,5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-,(11E)-;5,9-Methanocycloocta[b]pyridin-2(1H)-one,5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-,(5α,9β,11E)-(±)-;(11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one;(±)-Huperzine A;5,9-Methanocycloocta[b]pyridin-2(1H)-one,5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-,(5α,9β,11E)-;Fordine;103735-86-0;912960-35-1;687989-75-9
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CAS No:
Description
Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value:Target: AChEHuperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be
(11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one Basic Attributes
242.32
242.32
600-320-6
Characteristics
58.88000
0.71
1.20±0.1 g/cm3(Predicted)
505.0±50.0 °C(Predicted)
259.2±30.1 °C
1.626
2-8°C
Safety Information
UN 1544 6.1/PG 2
3
23/24/25-36/37/38
26-36/37/39-45
PB9185700
T
P261-P280-P301 + P310-P305 + P351 + P338-P311
H301 + H311 + H331-H315-H319-H335
(11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one Use and Manufacturing
Huperzine A is used for dementia in Alzheimer’s disease and for muscle weakness in myasthenia gravis.
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(11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one
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