Methyl 3,6-dichloropyridazine-4-carboxylate
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Methyl 3,6-dichloropyridazine-4-carboxylate
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CAS No:
286946-24-5
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Formula:
C6H4Cl2N2O2
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Chemical Name:
Methyl 3,6-dichloropyridazine-4-carboxylate
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Synonyms:
Methyl 3,6-dichloropyridazine-4-carboxylate;Methyl 3,6-dichloro-pyrid...;Methyl 3,6-dichloropyridazine-3-carboxylate;4-Pyridazinecarboxylic acid, 3,6-dichloro-, methyl ester;3,6-Dichloro-pyridazin-4-carboxylic acid methyl ester
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CAS No:
Methyl 3,6-dichloropyridazine-4-carboxylate Basic Attributes
207.01416
205.964981
DTXSID50591357
2933990090
Methyl 3,6-dichloropyridazine-4-carboxylate Use and Manufacturing
To a solution of 3, 6-dichloro-4-carboxy-pyridazine (7.5 g, 38.9 mmol, Aldrich) in DCM (30 mL) and MeOH (10 mL) cooled to 0° C. was added a solution of (trimethylsilyl)diazomethane (2.0 M in hexane), slowly via pipette, until a persistent yellow color is observed. After addition was complete, the solvents were removed in vacuo. The crude product was purified by SiOEXAMPLE 53-{6-Bromo-2-fluoro-3-[2-(1H-pyrazolo[3, 4-c]pyridazin-3-yl)-ethyl]-phenoxy}-5-chloro-benzonitrile (I-5) Preparation of 3-(2, 4-difluoro-phenoxy)-pyridazine-4-carboxylic acid (30b)step 1-To a solution of 28a (7.5 g, 38.9 mmol, Aldrich) in DCM (30 mL) and MeOH (10 mL) cooled to 0° C. was added slowly via pipette, a solution of (trimethylsilyl)diazomethane (2.0 M in hexane) until a persistent yellow color is observed. After addition was complete, the solvents were removed in vacuo. The crude product was purified by SiOStep 1:
Computed Properties
Molecular Weight:207.01
XLogP3:1.6
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:205.9649828
Monoisotopic Mass:205.9649828
Topological Polar Surface Area:52.1
Heavy Atom Count:12
Complexity:179
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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Methyl 3,6-dichloropyridazine-4-carboxylate
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