3-Pyridazinecarboxylic acid, 4,6-dichloro-, methyl ester
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3-Pyridazinecarboxylic acid, 4,6-dichloro-, methyl ester
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CAS No:
372118-01-9
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Formula:
C6H4Cl2N2O2
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Chemical Name:
3-Pyridazinecarboxylic acid, 4,6-dichloro-, methyl ester
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Synonyms:
3-Pyridazinecarboxylic acid,4,6-dichloro-,methyl ester;4,6-Dichloropyridazine-3-carboxylic acid methyl ester;3-Methoxycarbonyl-4,6-dichloropyridazine;Methyl 4,6-dichloropyridazine-3-carboxylate
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CAS No:
3-Pyridazinecarboxylic acid, 4,6-dichloro-, methyl ester Basic Attributes
207.02
207.01
DTXSID30591259
2933990090
Safety Information
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
H302
|Warning|H302 (33.33%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
3-Pyridazinecarboxylic acid, 4,6-dichloro-, methyl ester Use and Manufacturing
Step 3 Compound 4, 6-dichloropyridazine-3-carboxylate 1a (199 mg, 0.96 mmol), 1- (4-aminophenyl) -4-methylpiperazin-2-one (197 mg, 0.96 mmol), Diisopropylethylamine (1.24 g, 9.60 mmol) and acetonitrile (5 mL) were mixed, heated to 90 C and stirred for 6 hours.After cooling to room temperature, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate / methanol = 100/0 to 1/1), The target product 6-chloro-4-((4- (4-methyl-2-oxopiperazin-1-yl) phenyl) amino) pyridazine-3-carboxylic acid methyl ester 103a (97 mg, yellow oily ), Yield: 27%.Compound Compound Compound Compound Compound 5-aminodihydroindole-1-carboxylic acid tert-butyl ester (200 mg, 0.77 mmol) and Compound 5-aminopyridine-2-carboxylic acid tert-butyl ester (300 mg, 1.54 mmol) was dissolved in anhydrous tetrahydrofuran (15 mL), Then add sodium hydride (60%, 618mg, 15.4mmol) in order.And Compound Compound
Computed Properties
Molecular Weight:207.01
XLogP3:1.6
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:205.9649828
Monoisotopic Mass:205.9649828
Topological Polar Surface Area:52.1
Heavy Atom Count:12
Complexity:179
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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3-Pyridazinecarboxylic acid, 4,6-dichloro-, methyl ester
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