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Clebopride

Clebopride structure

CAS No:
55905-53-8
Formula:
C20H24ClN3O2
Chemical Name:
Clebopride
Synonyms:
Benzamide,4-amino-5-chloro-2-methoxy-N-[1-(phenylmethyl)-4-piperidinyl]-;4-Amino-5-chloro-2-methoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamide;Clebopride;BRL 20596
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

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Description

4-amino-5-chloro-2-methoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamide is a member of piperidines.

Clebopride Basic Attributes

Molecular Weight：

373.88

Exact Mass：

373.88

EC Number：

259-885-9

UNII：

I0A84520Y9

DSSTox ID：

DTXSID7022831

ATC Code：

A - Alimentary tract and metabolism

HScode：

2933399090

Characteristics

PSA：

67.6

XLogP3：

4.23520

Density：

1.27 g/cm3

Melting Point：

194-195 °C

Boiling Point：

514.7ºC at 760 mmHg

Flash Point：

265.1ºC

Safety Information

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

MeSH Entry Terms：

clebopride

Clebopride Use and Manufacturing

Antiemetics.

Computed Properties

Molecular Weight:373.9
XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:373.1557047
Monoisotopic Mass:373.1557047
Topological Polar Surface Area:67.6
Heavy Atom Count:26
Complexity:450
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a highly selective benzamide dopamine receptor antagonist. It can promote gastrointestinal motility, accelerate gastrointestinal peristalsis, strengthen and coordinate gastrointestinal movement; it has the effect of inhibiting nausea and vomiting.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Clbopride Malate Tablets
Ingredients	The main ingredient of this product is clobopride. Its chemical name is N-(1-benzyl-4-piperidinyl)-4-amino-5-chloro-2-methoxybenzamide malate. Molecular formula: C24H30ClN3O7. Molecular weight: 507.974
Indication	Combination use with anticholinergic drugs may weaken the effect of this product and therefore they cannot be used at the same time.
Specifications	0.68 mg
Manufacturer	Hunan Jiudian Pharmaceutical Co., Ltd.