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Roxatidine

Roxatidine structure

CAS No:
78273-80-0
Formula:
C17H26N2O3
Chemical Name:
Roxatidine
Synonyms:
Acetamide,2-hydroxy-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-;2-Hydroxy-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]acetamide;Roxatidine;164066-66-4
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

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Roxatidine Basic Attributes

Molecular Weight：

306.4

Exact Mass：

306.40

UNII：

IV9VHT3YUM

DSSTox ID：

DTXSID30228937

ATC Code：

A - Alimentary tract and metabolism

HScode：

2933399090

Characteristics

PSA：

61.8

XLogP3：

1.87870

Density：

1.137 g/cm3

Melting Point：

59-60 °C

Boiling Point：

524.3ºC at 760 mmHg

Flash Point：

270.9ºC

Drug Information

MeSH：

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)|Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood. (See all compounds classified as Histamine H2 Antagonists.)

MeSH Entry Terms：

roxatidine

Roxatidine Use and Manufacturing

Anti-ulcerative.

Computed Properties

Molecular Weight:306.4
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:306.19434270
Monoisotopic Mass:306.19434270
Topological Polar Surface Area:61.8
Heavy Atom Count:22
Complexity:319
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes