2-Methoxyquinoline-3-boronic acid
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2-Methoxyquinoline-3-boronic acid
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CAS No:
886853-93-6
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Formula:
C10H10BNO3
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Chemical Name:
2-Methoxyquinoline-3-boronic acid
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Synonyms:
2-Methoxyquinoline-3-boronic acid;2-Methoxyquinolin-3-ylboronic acid;(2-methoxy-3-quinolinyl)boronic acid(SALTDATA: FREE);(2-methoxy-3-quinolinyl)boronic acid;3-Borono-2-methoxyquinoline
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CAS No:
Safety Information
Xi
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
2-Methoxyquinoline-3-boronic acid Use and Manufacturing
To a solution of to 2-methoxyquinoline (10.0 g, 62.8 mmol) and triisiopropylborate (17.86 g, 95.1 mmol) in THF (140 mL) at -78 2-methoxy-quinoline (20.0g, 126mmol), triisopropoxy borane(59.1g, 314mmol, Mixture of tetrahydrofuran (dehydrated) (200mL) and cooled to -78 .There was added n- butyllithium (in hexanes 1.6M, 86mL, 138mmol), stirred for 4 hours at -78 , The temperature was raised to room temperature over 5 hours.After the reaction, the addition of saturated NH4Cl solution (100mL), and was added until the pH of HCl (3M) solution be 5. Then, the suspended solids obtained by concentration of the organic layer was washed with water, and filtered to give the number of 2-methoxy-3-boronic acid (19.7g, 97.0mmol) (yield 77percent).
Computed Properties
Molecular Weight:203.00
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:203.0753733
Monoisotopic Mass:203.0753733
Topological Polar Surface Area:62.6
Heavy Atom Count:15
Complexity:215
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-Methoxyquinoline-3-boronic acid
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