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Pamidronate disodium

Pamidronate disodium structure

CAS No:
57248-88-1
Formula:
C3H11NO7P2.2Na
Chemical Name:
Pamidronate disodium
Synonyms:
Phosphonic acid,P,P′-(3-amino-1-hydroxypropylidene)bis-,sodium salt (1:2);Phosphonic acid,(3-amino-1-hydroxypropylidene)bis-,disodium salt;3-Amino-1-hydroxypropane-1,1-diphosphonic acid disodium salt;APD;Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate;CGP 23339A;Disodium pamidronate;Aredia;Pamidronate disodium;CGP 23339AE;Aminomux;Pamidronic acid disodium salt;APD (pharmaceutical);Disodium [3-amino-1-hydroxy-1-(hydroxy-oxidophosphoryl)propyl]-hydroxyphosphinate;Pamimed;1159812-33-5
Categories:
Active Pharmaceutical Ingredients > Fluid, Electrolyte, and Acid-base Balance

Description

Pamidronate disodium, a bisphosphonate drug, can help to strengthen bones.Target: OthersPamidronate belongs to the family of medications known as bisphosphonates. It is used to treat hypercalcemia (high blood calcium) by people who have cancer. Pamidronate is also used to treat cancer that has spread to bones (bone metastases) due to different types of tumours and multiple myeloma (cancer of the bone marrow). Pamidronate is also used to treat the symptoms of Paget's disease of bone.

Pamidronate disodium Basic Attributes

Molecular Weight：

279.03

Exact Mass：

278.964964 g/mol

EC Number：

260-647-1

DSSTox ID：

DTXSID5042667

HScode：

2931900090

Characteristics

PSA：

167 Å²

XLogP3：

-0.08660

Appearance：

white solid

Melting Point：

300 °C

Water Solubility：

H2O: 28 mg/mL

Storage Conditions：

2-8°C

Safety Information

Hazard category：

IRRITANT

Transport codes：

3077

wgk germany：

hazard class code：

22-48-41-37/38-20/21/22

safety instructions：

22-26-36/37/39-45

RTECS Number：

SZ6525000

Marks：

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P309+P311, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 5 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Pamidronate disodium Use and Manufacturing

A bisphosphonate antiresorptive agent; bone resorption inhibitor.It is used for excessive lytic bone destruction and its complications caused by tumor bone metastasis, such as bone pain, hypercalcemia, pathological fracture; Pagets disease of bone lesions; it can also be used for osteoporosis. For the treatment of hypercalcemia and osteoporosis

Computed Properties

Molecular Weight:297.05
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:4
Exact Mass:296.97552887
Monoisotopic Mass:296.97552887
Topological Polar Surface Area:168
Heavy Atom Count:16
Complexity:238
Covalently-Bonded Unit Count:4
Compound Is Canonicalized:Yes

Recommended Suppliers of Pamidronate disodium

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

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Pamidronate disodium salt.

CAS No.: 57248-88-1

Grade: Pesticide Grade

Content: 99%

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Hangzhou Dawn Ray Pharmaceutical Co.,Ltd Contact Supplier

CN
5 YRS

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Pamidronate disodium salt USP Pharmaceutical API The treatment of osteoporosis made in china

CAS No.: 57248-88-1

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Creative Enzymes Contact Supplier

US
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Pamidronate Disodium

CAS No.: 57248-88-1

Content: 99%

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