Ondansetron hydrochloride dihydrate
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Ondansetron hydrochloride dihydrate
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CAS No:
103639-04-9
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Formula:
C18H19N3O.ClH.2H2O
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Chemical Name:
Ondansetron hydrochloride dihydrate
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Synonyms:
4H-Carbazol-4-one,1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-,hydrochloride,hydrate (1:1:2);4H-Carbazol-4-one,1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-,monohydrochloride,dihydrate;Ondansetron hydrochloride dihydrate
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CAS No:
Description
Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.Target: 5- HT3 ReceptorIC50 Value: in vitro: 5-HT evoked transient inward currents (EC50 = 3.4 microM; Hill coefficient = 1.8) that were blocked by the 5-HT3 receptor antagonist ondansetron (IC50 = 103 pM) [1]. The 5-HT3A receptor antagonist ondansetron (0.3 nM) reversibly inhibited the 5-HT (30 microM) signal by 70% and at 3 nM it abolished the re
Characteristics
41.8 Ų
3.80190
white crystal powder
1.1±0.1 g/cm3
231-232 C
553.1°C at 760 mmHg
144.9±5.1 °C
1.523
H2O: >5mg/mL
−20°C
1.47E-12mmHg at 25°C
Safety Information
Ⅲ
6.1
UN 2811
25-36/37/38-50/53-41
45-37/39-26-61-39
FE6375500
T,Xi
P273-P280-P301 + P310-P305 + P351 + P338-P501
H301-H318-H410
|Danger|H301 (50%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P273, P280, P301+P310, P301+P312, P305+P351+P338, P310, P321, P330, P391, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Computed Properties
Molecular Weight:347.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:347.1400546
Monoisotopic Mass:347.1400546
Topological Polar Surface Area:40.8
Heavy Atom Count:24
Complexity:440
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Drug Function and Efficacy
This product is a selective 5-HT3 receptor antagonist. Its mechanism of action may be to antagonize the 5-HT3 receptors in the peripheral vagus nerve endings and central chemoreceptor areas, thereby blocking the vomiting reflex caused by factors such as chemotherapy and surgery that promote the release of 5-HT from intestinal chromaffin cells and excite the vagus afferent nerves. This product has high selectivity and no side effects such as extrapyramidal reactions and excessive sedation.
Registered Holders
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APITORIA PHARMA PRIVATE LTD
Active
United States
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SMS Pharmaceuticals Ltd
Active
United States
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HIKAL LTD
Active
United States
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Ondansetron hydrochloride dihydrate
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