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Tiapride hydrochloride

Tiapride hydrochloride structure

CAS No:
51012-33-0
Formula:
C15H24N2O4S.ClH
Chemical Name:
Tiapride hydrochloride
Synonyms:
Benzamide,N-[2-(diethylamino)ethyl]-2-methoxy-5-(methylsulfonyl)-,hydrochloride (1:1);Benzamide,N-[2-(diethylamino)ethyl]-2-methoxy-5-(methylsulfonyl)-,monohydrochloride;Tiapride hydrochloride;Luxoben;Tiapridal;Italprid;Gramalil;Tiapridex;Sereprile
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Tiapride hydrochloride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain. It is used to treat a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome.

Tiapride hydrochloride Basic Attributes

Molecular Weight：

364.89

Exact Mass：

364.12200

EC Number：

256-908-4

HScode：

2924299090

Characteristics

PSA：

84.1

XLogP3：

3.62790

Density：

1.15 g/cm3

Melting Point：

approximate 200℃ (dec.)

Boiling Point：

498.1ºC at 760 mmHg

Flash Point：

255.1ºC

Water Solubility：

52.5 [ug/mL]

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

CV4203800

Precautionary statement(s)：

P201, P202, P261, P264, P271, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

Tiapride hydrochloride Use and Manufacturing

Dopamine antagonist;Antidyskinetic

Computed Properties

Molecular Weight:364.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:364.1223562
Monoisotopic Mass:364.1223562
Topological Polar Surface Area:85.3
Heavy Atom Count:23
Complexity:443
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product belongs to the benzamide antipsychotic drug, which has an inhibitory effect on the hyperfunction of dopaminergic nerves in the midbrain limbic system and an antagonistic effect on dopaminergic nerve movement disorders in the striatum, thereby producing a calming and sedative effect. It is characterized by its good effect on sensory and motor neurological diseases and psychomotor behavioral disorders. Animal experiments have confirmed that this product can block the conduction of pain impulses through the spinal thalamic tract to the reticular formation. The analgesic effect of this drug may be related to the integration of pain impulses by the thalamus. In addition, it has an antiemetic effect.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Tiapride Hydrochloride Tablets
Ingredients	The main ingredient of this product is tiapride hydrochloride.
Indication	This product can enhance the effects of central nervous system depressants and can be used in combination with analgesics, sedatives, hypnotics, tranquilizers, antidepressants, antiparkinsonian drugs and antiepileptic drugs. However, at the beginning of treatment, the dose of the combined central nervous system depressant should be reduced.
Specifications	0.1g

Tiapride Hydrochloride Tablets
Ingredients	The main ingredient of this product is tiapride hydrochloride.
Indication	This product can enhance the effects of central nervous system depressants and can be used in combination with analgesics, sedatives, hypnotics, tranquilizers, antidepressants, antiparkinsonian drugs and antiepileptic drugs. However, at the beginning of treatment, the dose of the combined central nervous system depressant should be reduced.
Specifications	0.1g
Manufacturer	Shandong Mingren Freda Pharmaceutical Co., Ltd.

Tiapride Hydrochloride Tablets
Ingredients	The main ingredient of this product is tiapride hydrochloride.
Indication	This product can enhance the effects of central nervous system depressants and can be used in combination with analgesics, sedatives, hypnotics, tranquilizers, antidepressants, antiparkinsonian drugs and antiepileptic drugs. However, at the beginning of treatment, the dose of the combined central nervous system depressant should be reduced.
Specifications	100mg

See More Related Drugs

Registered Holders

ICROM S.P.A.

Italy
Active
株式会社パーマケム・アジア

Japan
Active
Daito Pharmaceutical Co.,Ltd.

Japan
Active

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