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Mianserin hydrochloride

Mianserin hydrochloride structure

CAS No:
21535-47-7
Formula:
C18H20N2.ClH
Chemical Name:
Mianserin hydrochloride
Synonyms:
Dibenzo[c,f]pyrazino[1,2-a]azepine,1,2,3,4,10,14b-hexahydro-2-methyl-,hydrochloride (1:1);Dibenzo[c,f]pyrazino[1,2-a]azepine,1,2,3,4,10,14b-hexahydro-2-methyl-,monohydrochloride;Mianserin hydrochloride;Tolvon;GB 94;Mianserine hydrochloride;Org GB 94;Toluon;Bolvidon;Athymil;Tetramide;Tolvin;Lantanon;Norval;NSC 292267;2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride;78644-54-9
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Mianserin hydrochloride is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.Target: H1 receptorMianserin is a psychoactive drug of the tetracyclic antidepressant (TeCA) therapeutic family. It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant, anxiolytic (anti-anxiety), hypnotic (sedating), antiemetic (nausea and vomiting-attenuating), orexigenic (appetite-stimulating), and antihistamine effe

A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.

Mianserin hydrochloride Basic Attributes

Molecular Weight：

300.83

Exact Mass：

300.139313

EC Number：

244-426-7

NSC Number：

759590|292267

HScode：

2933990090

Characteristics

PSA：

6.5

Density：

1.18 g/cm3

Melting Point：

282-284 °C

Boiling Point：

411.3°C at 760 mmHg

Flash Point：

9℃

Water Solubility：

soluble in water, ethanol, methanol, and dimethylformamide.H2O: 3.4 mg/mL

Storage Conditions：

2-8°C

Toxicity：

Oral-rat LD50: 780 mg/kg; Oral-Mouse LD50: 224 mg/kg

Flammability characteristics：

Thermal decomposition releases toxic nitrogen oxides and hydrogen chloride gas

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

wgk germany：

hazard class code：

22-39/23/24/25-23/24/25-11

safety instructions：

7-16-36/37-45

RTECS Number：

HP8780000

Marks：

Xn,Xi,T,F

Storage features：

Warehouse ventilated, low temperature and dry

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P264, P270, P281, P301+P312, P307+P311, P308+P313, P321, P330, P405, and P501|Aggregated GHS information provided by 276 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. (See all compounds classified as Adrenergic alpha-Antagonists.)|Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)|A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake. (See all compounds classified as Antidepressive Agents, Second-Generation.)|Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

MeSH Entry Terms：

Hydrochloride, Mianserin

Mianserin hydrochloride Use and Manufacturing

Serotonin receptor antagonist. Antidepressant.

Computed Properties

Molecular Weight:300.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:300.1393264
Monoisotopic Mass:300.1393264
Topological Polar Surface Area:6.5
Heavy Atom Count:21
Complexity:342
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Mianserin hydrochloride
Ingredients	Mianserin hydrochloride
Manufacturer	Renhetang Pharmaceutical Co., Ltd.

Mianserin Hydrochloride Tablets
Ingredients	The main ingredient of this product is mianserin hydrochloride. Chemical name: 1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazine[1,2-a]azepine hydrochloride. Molecular formula: C18H20N2?HCL Molecular weight: 300.08
Indication	1. Mianserin hydrochloride can intensify the inhibitory effect of ethanol on the central nervous system, so patients should be advised to abstain from alcohol during treatment. 2. Mianserin hydrochloride should not be taken at the same time as monoamine oxidase inhibitors, and should not be taken within two weeks of stopping monoamine oxidase inhibitors. 3. Mianserin hydrochloride has no interaction with benzyldimethylpiperidone, clonidine, methyldopa, pheniridine or propranolol (used alone or in combination with hydralazine), but it is recommended to monitor the blood pressure of patients taking antihypertensive drugs at the same time.
Specifications	30 mg
Manufacturer	Renhetang Pharmaceutical Co., Ltd.

Registered Holders

Excella GmbH & Co. KG

Germany
Active
Renhetang Pharmaceutical Co., Ltd.

China
Active
ARCHIMICA S.P.A

European Union
Active

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