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SYR-472

SYR-472 structure

CAS No:
1029877-94-8
Formula:
C18H20FN5O2.C4H6O4
Chemical Name:
SYR-472
Synonyms:
SYR-472 succinate;Trelagliptin Succinate (SYR-472);SYR 111472 succinate;Trelagliptin succinat;SYR-472 Trelagliptin succinat;Trelagliptin succinate(SRY-472);Trelagliptin succinateSYR 111472 succinate;SRY-472
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Trelagliptin(SYR-472) is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D). IC50 value:Target: DPP4Two Phase II clinical studies have been completed with Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus. Phase III clinical studies with trelagliptin in Japan to evaluate its safety and efficacy in a once-weekly oral treatment regimen. Currently, all available DPP-4 inhibitors are dosed once-dail

SYR-472 Basic Attributes

Molecular Weight：

475.477

Exact Mass：

475.187

UNII：

4118932Z90

DSSTox ID：

DTXSID00145602

Characteristics

PSA：

168

XLogP3：

1.23468

Appearance：

White to off-white solid

Drug Information

MeSH Entry Terms：

SYR-472

Computed Properties

Molecular Weight:475.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:6
Exact Mass:475.18671173
Monoisotopic Mass:475.18671173
Topological Polar Surface Area:168
Heavy Atom Count:34
Complexity:750
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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