Granisetron hydrochloride
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Granisetron hydrochloride
structure -
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CAS No:
107007-99-8
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Formula:
C18H24N4O.ClH
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Chemical Name:
Granisetron hydrochloride
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Synonyms:
1H-Indazole-3-carboxamide,1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-,hydrochloride (1:1);1H-Indazole-3-carboxamide,1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-,monohydrochloride,endo-;1H-Indazole-3-carboxamide,1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-,monohydrochloride;9-Azabicyclo[3.3.1]nonane,1H-indazole-3-carboxamide deriv.;BRL 43694A;Granisetron hydrochloride;Kytril
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CAS No:
Description
It is white or yellowish white crystalline powder and is odorless. It is easily soluble in water but hardly soluble in methanol, extremely hardly to be dissolved in ethanol and almost insoluble in ether. It has a melting point of 290-292 ℃. For acute toxicity LD50, female mice, male and female rats (mg/kg): 17, 25, 14, 16, respectively. Intravenous injection.
A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.
Granisetron hydrochloride Basic Attributes
348.87
348.171692
1312995-182-4
759839|672814
DTXSID7049057
29399990
Characteristics
50.16000
3.44920
White to Off-White Crystalline Solid
1.33g/cm3
290-292 °C
532ºC at 760mmHg
275.6ºC
1.69
H2O: >10mg/mL
room temp
0mmHg at 25°C
Safety Information
NONH for all modes of transport
3
22-62-37/38-36/37/38-36
26-36-37-24/25
NK7882200
Xn,Xi
P301 + P312 + P330
H302
|Warning|H302 (99%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 100 companies from 8 notifications to the ECHA C&L Inventory.
Drug Information
Drug: Granisetronhydrochloride
Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)|Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)
1-Methyl-N-(endo-9-Methyl-9-Azabicyclo(3.3.1)non-3-yl)-1H-Indazole-3-Carboxamide
Granisetron hydrochloride Use and Manufacturing
A specific serotonin (5HT3) receptor antagonist. Used as an antiemetic. Granisetron HCl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptor
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:348.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:348.1716891
Monoisotopic Mass:348.1716891
Topological Polar Surface Area:50.2
Heavy Atom Count:24
Complexity:442
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
This product is a highly selective 5HT3 receptor antagonist, which has a good preventive and therapeutic effect on nausea and vomiting caused by radiotherapy, chemotherapy and surgery. It inhibits the occurrence of nausea and vomiting by antagonizing the 5HT3 receptors in the central chemoreceptor area and peripheral vagus nerve endings.
Registered Holders
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ORBION PHARMACEUTICALS PRIVATE LTD
Active
United States
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SWATI SPENTOSE PRIVATE LTD
Active
United States
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SYN-TECH CHEM AND PHARM CO LTD
Active
United States
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