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Quetiapine fumarate

Quetiapine fumarate structure

CAS No:
111974-72-2
Formula:
C21H25N3O2S.¹/2C4H4O4
Chemical Name:
Quetiapine fumarate
Synonyms:
Ethanol,2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-,(2E)-2-butenedioate (2:1);Ethanol,2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-,(E)-2-butenedioate (2:1) (salt);Ethanol,2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-,(2E)-2-butenedioate (2:1) (salt);Dibenzo[b,f][1,4]thiazepine,ethanol deriv.;ICI 204636;Seroquel;ZM 204636;Quetiapine fumarate;ZD 5077;Quetiapine hemifumarate;Loquen;Quitpin;Quetros;Kwetaplex
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

White Crystalline SolidWhite crystalline powder. Quetiapine fumarate is an antipsychotic, successfully developed by the AstraZeneca United States, it interacts with a variety of neurotransmitter receptors, in the brain, it displays high degree affinity for serotonin (5-HT2) receptor, and it is greater than dopamine D1 and D2 dopamine receptor affinity in the brain. Quetiapine also has high affinity for histamine H1 receptor and adrenergic α1 receptors, and low affinity for α2 receptors, but i

Quetiapine fumarate Basic Attributes

Molecular Weight：

883.09

Exact Mass：

383.166748

EC Number：

1308068-626-2

HScode：

29349990

Characteristics

PSA：

221.80000

XLogP3：

4.04660

Appearance：

Solid

Melting Point：

174-176°C

Boiling Point：

556.5ºC at 760 mmHg

Flash Point：

9℃

Water Solubility：

DMSO: >10mg/mL

Storage Conditions：

-20°C Freezer

Vapor Pressure：

5.39X10-14 mm Hg at 25 °C (est)

PKA：

7.06None

Safety Information

Packing level：

III

Hazard category：

Transport codes：

UN1230 - class 3 - PG 2 - Methanol, solution

wgk germany：

hazard class code：

22-50/53-52/53-39/23/24/25-23/24/25-11

safety instructions：

60-61-45-36/37-16

RTECS Number：

KK3605000

Marks：

Xn,N,T,F

Stability/Shelf Life：

Stable under recommended storage conditions.

Precautionary statement(s)：

P273

Hazard Statements：

H302-H400

Quetiapine fumarate Use and Manufacturing

antihypertensive adrenergic receptor blocking agent with selective alpha1- and nonselective beta-adrenergic receptor blocking actions in a single substance.

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Quetiapine Fumarate
Manufacturer	Fuan Pharmaceutical Group Chongqing BOSEN Pharmaceutical Co., Ltd.

Quetiapine Fumarate Tablets
Specifications	25mg

Quetiapine Fumarate Sustained Release Tablets
Specifications	300mg

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Registered Holders

CHEMECA DRUGS PRIVATE LTD

United States
Active
RAKS PHARMA PVT LTD

United States
Active
MEGAFINE PHARMA P LTD

United States
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