Trimetazidine dihydrochloride
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Trimetazidine dihydrochloride
structure -
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CAS No:
13171-25-0
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Formula:
C14H22N2O3.2ClH
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Chemical Name:
Trimetazidine dihydrochloride
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Synonyms:
Piperazine,1-[(2,3,4-trimethoxyphenyl)methyl]-,hydrochloride (1:2);Piperazine,1-(2,3,4-trimethoxybenzyl)-,dihydrochloride;Piperazine,1-[(2,3,4-trimethoxyphenyl)methyl]-,dihydrochloride;Trimetazidine dihydrochloride;Vastarel;S 4004;1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride;Vastarel F;Yoshimilon;Kyurinett;Trivedon
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Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
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CAS No:
Description
Crystalline SolidTrimetazidine dihydrochloride is the dihydrochloride salt of Trimetazidine. It is a drug used for the treatment of angina pectoris. It is capable of improving the left ventricular function in diabetic patients suffering coronary heart disease as well as treating the symptoms of patients suffering heart failure of different etiologies. It takes effects through acting as an anti- ischemic metabolic agent being capable of improving the utilization efficiency of myocardial glucose
Trimetazidine hydrochloride is an aromatic amine.|A vasodilator used in angina of effort or ischemic heart disease.
Trimetazidine dihydrochloride Basic Attributes
339.26
338.116394
236-117-0
48V6723Z1P
DTXSID1045407
29339900
Characteristics
43
2.98830
crystalline solid
225-228 °C
364ºC at 760 mmHg
174ºC
Freely soluble in water, sparingly soluble in alcohol.
Refrigerator
1.73E-05mmHg at 25°C
LD50 in male, female mice, rats (mg/kg): 91, 107, 124, 124 i.v.; 264, 245, 327, 288 i.p.; 528, 608, 1147, 987 orally (Harpey)
159.9 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
IRRITANT
NONH for all modes of transport
3
22-36/37/38
26-36
TM2976100
Xn,Xi
P261-P305 + P351 + P338
H302-H315-H319-H335
|Warning|H302 (98.17%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 109 companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Treatment of ischaemic coronary artery disorders
Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)
Centrophène
Trimetazidine dihydrochloride Use and Manufacturing
Coronary vasodilator. Antianginal
Human Drugs -> EU pediatric investigation plans
Computed Properties
Molecular Weight:339.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:338.1163980
Monoisotopic Mass:338.1163980
Topological Polar Surface Area:43
Heavy Atom Count:21
Complexity:259
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Drug Function and Efficacy
By protecting the energy metabolism of cells under hypoxia or ischemia, preventing the decrease of intracellular ATP levels, thus ensuring the normal function of ion pumps and the normal operation of transmembrane sodium-potassium flow, and maintaining the stability of the intracellular environment. 1 Helps maintain the energy metabolism of the heart and nerve sensory organs under ischemia and hypoxia. 2 Reduces intracellular acidosis and changes in transmembrane ion flow caused by ischemia. 3 Reduces the movement and infiltration of multinuclear neutrophils during ischemia and myocardial reperfusion, and reduces the scope of experimental infarction. 4 While producing this effect, it has no significant effect on hemodynamics. Human studies have shown that trimetazidine can: 1 Increase coronary blood flow reserve, thereby delaying the occurrence of exercise-induced ischemia from the 15th day of treatment. 2 Limit rapid fluctuations in blood pressure without significant changes in heart rate. 3 Significantly reduce the frequency of angina attacks. 4 Significantly reduce the use of glyceryl trinitrate.
Registered Holders
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USV PRIVATE LIMITED
Active
India
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Guangzhou Greensyn Co., Ltd.
Active
China
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Suzhong Pharmaceutical Group Co., Ltd.
Active
China
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