Diammonium glycyrrhizinate
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Diammonium glycyrrhizinate
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CAS No:
79165-06-3
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Formula:
C42H62O16.2H3N
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Chemical Name:
Diammonium glycyrrhizinate
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Synonyms:
18A-DIAMMONIUM GLYCYRRHIZINATE;18α-DIAMMONIUM GLYCYRRHIZINATE;GLYCYRRHIZICACIDDIAMMONIUMSALT;Diammonium glycyrrhizinate;Diammonium Glycyrrhizinat;DiaMMoniuM Glycyrrhizate;a-D-Glucopyranosiduronic acid;N-(3-CHLOROBENZYL)-N-PHENYLBENZENESULFONAMIDE
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CAS No:
Description
Diammonium Glycyrrhizinate, isolated from the licorice root, is a widely used anti-inflammatory agent[1].
A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.
Diammonium glycyrrhizinate Basic Attributes
856.997
856.456909
1308068-626-2
A9ZZD585U6
DTXSID90229561
A - Alimentary tract and metabolism
Safety Information
|Warning|H302 (18.18%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501|Aggregated GHS information provided by 108 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)
Acid, Glycyrrhizic
Diammonium glycyrrhizinate Use and Manufacturing
Anti-allergic, clearing away heat and detoxification, used to treat various types of hepatitis
.alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, ammonium salt (1:1): ACTIVE
Food additives -> Flavoring Agents|Cosmetics -> Humectant; Skin conditioning
Flavoring Agents
Computed Properties
Molecular Weight:857.0
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:18
Rotatable Bond Count:7
Exact Mass:856.45688409
Monoisotopic Mass:856.45688409
Topological Polar Surface Area:269
Heavy Atom Count:60
Complexity:1730
Defined Atom Stereocenter Count:19
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Drug Function and Efficacy
It has certain anti-inflammatory, liver cell membrane protection and liver function improvement effects. It can reduce the increase of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) caused by carbon tetrachloride, thioacetamide and D-aminogalactic acid, reduce the damage of D-aminogalactic acid to the liver and improve the chronic damage of immune factors to the liver.
Registered Holders
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Shenyang Yaoda Leiyunshang Pharmaceutical Co., Ltd.
Active
China
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Suzhong Pharmaceutical Group Co., Ltd.
Active
China
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Chongqing Pharscin Pharmaceutical Co., Ltd.
Active
China
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