2-METHYL-4-PHENYL-5-PYRIMIDINECARBOXYLIC ACID

To a mixture of A-14 (135 mg, 0.63 mmol), B-1 (150 mg, 0.53 mmol) and DIPEA (273 mu, 1 .60 mmol) in dry ACN (2.0 mL) is added CIP (191 mg, 0.68 mmol) and the mixture is stirred at RT for 2 days. ACN/H20 is added and the mixture is purified by prep. HPLC-MS (using a solvent gradient H20/ACN with NH4OH) to afford 133 mg of Example 17. ESI-MS: 445 [M+Na]+; HPLC (Rt): 1 .04 min (method G).Step A: tert-Butyl (2-methyl-4-phenylpyrimidin-5-yl)carbamate To a suspension of To a suspension of Example 188 N-[(2r, 5s)-5-hydroxyadamantan-2-yl]-2-methyl-4-phenylpyrimidine-5-carboxamide O-(7-Azabenzotriazol-1-yl)-N, N, N', N'-tetramethyluronium hexafluorophosphate (456 mg, 1.2 mmol) was added in one portion to Prepared from Intermediate 132 by the same process used for Intermediate 29; 1H NMR (400.13 MHz, DMSO-d6) delta 2.71 (3H, s), 7.45-7.53 (3H, m), 7.58-7.63 (2H, m), 8.98 (1H, s), 13.44 (1H, s) m/z (ESI+) (M+H)+=215; HPLC tR=1.19 min.EXAMPLE 168 2-methyl-5-[(2-methyl-1-pyrrolidinyl)carbonyl]-4-phenylpyrimidine The desired product can be prepared by substituting

Molecular Weight:214.22
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:214.074227566
Monoisotopic Mass:214.074227566
Topological Polar Surface Area:63.1
Heavy Atom Count:16
Complexity:251
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes