PYRIDINE, 2-CHLORO-4-HYDRAZINO-

Pale yellow crystalline powder

A solution of 4-Bromo-2-chloropyridine V (50 g, 260 mmol, 1.0 equiv ·) was dispersed in 96 ml of 80% hydrazine hydrate (4.794mol, 12 equiv.), And the reaction was performed in an oil bath at 60 C for 48 hours. TLC showed the reaction At the end, the pH of 2 W sodium hydroxide solution was adjusted to 12, EA / THF (2: 1) was extracted, and the organic phase was concentrated to obtain 31.3 g of a pale yellow solid, namely Step 2: 3-(2-chlorophenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-4-carbaldehyde To a solution of 1-(2-chlorophenyl)ethanone (1.08 mL, 8.36 mmol) in AcOH (33 mL) was added

Molecular Weight:143.57
XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:143.0250249
Monoisotopic Mass:143.0250249
Topological Polar Surface Area:50.9
Heavy Atom Count:9
Complexity:88.3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes