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(2′R)-2′-Deoxy-2′-fluoro-2′-methyluridine

(2′R)-2′-Deoxy-2′-fluoro-2′-methyluridine structure

CAS No:
863329-66-2
Formula:
C10H13FN2O5
Chemical Name:
(2′R)-2′-Deoxy-2′-fluoro-2′-methyluridine
Synonyms:
Uridine,2′-deoxy-2′-fluoro-2′-methyl-,(2′R)-;(2′R)-2′-Deoxy-2′-fluoro-2′-methyluridine;RO 2433;PSI-6206;GS 331007;1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione;(2′R)-2′-Deoxy-2′-fluoro-2′-methyluridine
Categories:
Pharmaceutical Intermediates > Antivirals

Description

PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.

(2′R)-2′-Deoxy-2′-fluoro-2′-methyluridine Basic Attributes

Molecular Weight：

260.2190232

Exact Mass：

260.22

EC Number：

1308068-626-2

UNII：

44V7045CXS

DSSTox ID：

DTXSID30462011

HScode：

2934999090

Characteristics

PSA：

99.1

XLogP3：

-1.1

Appearance：

Off-white solid

Density：

1.55

Melting Point：

237.3-238.0 °C

Refractive Index：

1.596

Safety Information

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

2'-deoxy-2'-fluoro-2'-C-methyluridine

(2′R)-2′-Deoxy-2′-fluoro-2′-methyluridine Use and Manufacturing

sofosbuvir/1190307-88-0 intermediate

Computed Properties

Molecular Weight:260.22
XLogP3:-1.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:260.08084968
Monoisotopic Mass:260.08084968
Topological Polar Surface Area:99.1
Heavy Atom Count:18
Complexity:415
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of (2′R)-2′-Deoxy-2′-fluoro-2′-methyluridine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Learn More Other Chemicals

(2′R)-2′-Deoxy-2′-fluoro-2′-methyluridine

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