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10-Nitrocamptothecin

10-Nitrocamptothecin structure

CAS No:
86639-62-5
Formula:
C20H15N3O6
Chemical Name:
10-Nitrocamptothecin
Synonyms:
RUBETICAN;CAMPTOTHECIN, 9-NITRO-20(S)-;9-NITRO-CPT;4α-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;9-Nitro-20(S)-camptothecine;(S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(S)-4-Ethyl-4-hydroxy-9-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-di
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

ChEBI: Rubitecan is a pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin. It has a role as an antineoplastic agent, an EC 5.99.1.2 (DNA topoisomerase) inhibitor and a prodrug. It is a pyranoindolizinoquinoline, a C-nitro compound, a semisynthetic derivative, a tertiary alcohol and a delta-lactone.

10-Nitrocamptothecin Basic Attributes

Molecular Weight：

393.35

Exact Mass：

393.096100

Characteristics

PSA：

127.24000

XLogP3：

1.36

Density：

1.63±0.1 g/cm3(Predicted)

Boiling Point：

827.4±65.0 °C(Predicted)

Flash Point：

454.2±34.3 °C

Refractive Index：

1.762

PKA：

11.17±0.20(Predicted)

10-Nitrocamptothecin Use and Manufacturing

Whether cells can divide depends on the two key points of entering S phase and M phase. Studies have found that 10-Nitrocamptothecin can induce apoptosis. After administration, both S phase and G2M phase of cell growth are delayed. Inhibition occurred throughout the cell cycle and was found to be dose- and time-dependent.

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CAS No.: 86639-62-5

Grade: Pharmaceutical Grade

Content: 99%

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