6-Fluoro-2-methyl-3-pyridinecarboxylic acid
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6-Fluoro-2-methyl-3-pyridinecarboxylic acid
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CAS No:
884494-97-7
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Formula:
C7H6FNO2
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Chemical Name:
6-Fluoro-2-methyl-3-pyridinecarboxylic acid
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Synonyms:
3-Pyridinecarboxylic acid,6-fluoro-2-methyl-;6-Fluoro-2-methyl-3-pyridinecarboxylic acid;6-Fluoro-2-methylnicotinic acid
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CAS No:
6-Fluoro-2-methyl-3-pyridinecarboxylic acid Basic Attributes
155.13
155.13
DTXSID00654269
2933399090
Safety Information
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
6-Fluoro-2-methyl-3-pyridinecarboxylic acid Use and Manufacturing
6-Fluoro-2-methylnicotinic acid (400 mg, 2.58 mmol) and DIPEA (900 muL, 5.16 mmol) were added to a solution of (R)-3-[l-(3-isopropyl-[l, 2, 4]oxadiazol-5-yl)piperidin-4-yl]- butylamine (Preparation 14, 690 mg, 2.58 mmol) in NMP (3 mL) and the resulting solution heated in the microwave at 1000C for 7 h. The reaction mixture was diluted with EtOAc, washed with IM HCl and the acidic washings basified to pH 5 with IM NaOH, before being extracted with EtOAc. The organic extracts were washed with H2O, brine, dried (MgSO4), filtered and concentrated in vacuo. Purification by column chromatography (EtOAc-IH-AcOH; 69:30:1) afforded the title compound: RT = 2.70 min; mlz (ES+) = 402.69 [M + H]+.
Computed Properties
Molecular Weight:155.13
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:155.03825660
Monoisotopic Mass:155.03825660
Topological Polar Surface Area:50.2
Heavy Atom Count:11
Complexity:163
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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6-Fluoro-2-methyl-3-pyridinecarboxylic acid
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