 Home > Encyclopedia > 1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, 4-methylbenzenesulfonate (1:1)

1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, 4-methylbenzenesulfonate (1:1)

1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, 4-methylbenzenesulfonate (1:1) structure

CAS No:
115964-29-9
Formula:
C19H15F3N4O3.C7H8O3S
Chemical Name:
1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, 4-methylbenzenesulfonate (1:1)
Synonyms:
1,8-Naphthyridine-3-carboxylic acid,7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-,4-methylbenzenesulfonate (1:1);1,8-Naphthyridine-3-carboxylic acid,7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-,mono(4-methylbenzenesulfonate);T 3262;A 64730;Tosufloxacin tosylate;Tosuxacin;Ozex;144742-63-2
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

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Description

White to Off-White SolidTosufloxacin tosylate is a new fluoroquinolone antibacterial structurally related to temafloxacin. Mechanistically, it is a microbial DNA topoisomerase inhibitor, useful against beta-lactamase producing organisms. Tosufloxacin tosylate is reported to be particularly effective against Salmonella enteritidis.

1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, 4-methylbenzenesulfonate (1:1) Basic Attributes

Molecular Weight：

576.54

Exact Mass：

576.129028

HScode：

29339900

Characteristics

PSA：

163

XLogP3：

5.12640

Density：

1.558g/cm3

Melting Point：

251-252°C

Boiling Point：

614.4ºC at 760mmHg

Storage Conditions：

Refrigerator

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

RTECS Number：

QN2791000

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, 4-methylbenzenesulfonate (1:1) Use and Manufacturing

Useful as a therapeutic antimicrobial for the treatment of respiratory infections

Drug Function and Efficacy

This product is a broad-spectrum quinolone antibacterial drug, which inhibits bacterial DNA gyrase and hinders bacterial DNA replication to achieve bacteriostatic and bactericidal effects. It has strong antibacterial activity against Gram-positive bacteria, Gram-negative bacteria, anaerobic bacteria, etc.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Toloxacin Tosylate Capsules
Ingredients	The main ingredient of this product is toloxacin tosylate, and its chemical name is: (±) 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid p-toluenesulfonate monohydrate. The chemical structural formula is: Molecular formula: C19H15F3N4O3·C7H8O3S·H2O Molecular weight: 594.56
Indication	Avoid taking it at the same time with non-steroidal anti-inflammatory analgesics such as phenylacetic acid and fenbutic acid (which may cause spasms). Avoid taking it at the same time with antacids or iron preparations containing calcium or magnesium (which may weaken the effect of this product).
Specifications	0.15g
Manufacturer	Han Hui Pharmaceuticals Company Limited

Toloxacin Tosylate
Specifications	API

Toloxacin Tosylate
Manufacturer	Zhejiang Hisun Pharmaceutical Co., Ltd.

Registered Holders

Zhejiang Hisun Pharmaceutical Co., Ltd.

China
Active
HeBei Guolong Pharmaceutical Co., Ltd.

China
Inactive

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Tosufloxacin tosylate

CAS No.: 115964-29-9

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Guide of 1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, 4-methylbenzenesulfonate (1:1)

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, 4-methylbenzenesulfonate (1:1)

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