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Ofloxacin hydrochloride

Ofloxacin hydrochloride structure

CAS No:
118120-51-7
Formula:
C18H20FN3O4.xClH
Chemical Name:
Ofloxacin hydrochloride
Synonyms:
7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid,9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-,hydrochloride (1:?);7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid,9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-,hydrochloride,(±)-;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid,9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-,hydrochloride;Ofloxacin hydrochloride
Categories:
Active Pharmaceutical Ingredients > Inhibitor Drugs

Description

A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.

Ofloxacin hydrochloride Basic Attributes

Molecular Weight：

397.83

Exact Mass：

397.120453

Characteristics

PSA：

73.3

XLogP3：

2.34890

Density：

1.48g/cm3

Boiling Point：

571.5ºC at 760mmHg

Flash Point：

299.4ºC

Drug Information

MeSH：

Substances capable of killing agents causing urinary tract infections or of preventing them from spreading. (See all compounds classified as Anti-Infective Agents, Urinary.)|Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)|Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP1A2. (See all compounds classified as Cytochrome P-450 CYP1A2 Inhibitors.)

MeSH Entry Terms：

DL 8280

Ofloxacin hydrochloride Use and Manufacturing

Fully synthetic antibiotics, used to treat diseases caused by various bacterial infections

Computed Properties

Molecular Weight:397.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:2
Exact Mass:397.1204620
Monoisotopic Mass:397.1204620
Topological Polar Surface Area:73.3
Heavy Atom Count:27
Complexity:634
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes