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Vitamin K

Vitamin K structure

CAS No:
12001-79-5
Chemical Name:
Vitamin K
Synonyms:
Vitamin K;Kanavit
Categories:
Active Pharmaceutical Ingredients > Drug Metabolism

Description

Vitamin K is a group of fat soluble vitamins, important for the function of numerous proteins within the body, such as the coagulation factors, osteocalcin and matrix-Gla protein.

2-methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)naphthalene-1,4-dione is a member of 1,4-naphthoquinones.|A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.

Vitamin K Basic Attributes

Molecular Weight：

450.7

Exact Mass：

450.35000

EC Number：

201-564-2

NSC Number：

270681

DSSTox ID：

DTXSID1052743

Characteristics

PSA：

34.1

XLogP3：

9.15760

Appearance：

viscous liquid

Density：

0.984 g/mL at 25 °C(lit.)

Melting Point：

−20 °C(lit.)

Boiling Point：

140-145 deg C @ 0.001 mm Hg

Flash Point：

>230 °F

Refractive Index：

n20/D 1.527(lit.)

Water Solubility：

SOL IN FATS

Storage Conditions：

2-8°C

Safety Information

wgk germany：

RTECS Number：

QJ5800000

Stability/Shelf Life：

Phytonadione is stable to heat and moisture and may be autoclaved.

Precautionary statement(s)：

P273, P501

Hazard Statements：

H413

GHS Classification：

H413 (100%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]|P273, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins are known. The drugs are used to control massive hemorrhage and in other coagulation disorders. (See all compounds classified as Antifibrinolytic Agents.)|Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body. (See all compounds classified as Vitamins.)

MeSH Entry Terms：

Vitamin K

Vitamin K Use and Manufacturing

Uses

This product is a hemostatic drug. It is used for prevention and treatment of prothrombin hypothyroidism, vitamin K deficiency, spontaneous hemorrhage of neonates, bleeding caused by excessive consumption of bis-coumarin, salicylic acid, etc. It is effective against colic caused by biliary ascariasis. Side effects of oral administration often cause gastrointestinal reactions such as nausea and vomiting.

Manufacturing Info：

Vitamin K: INACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:450.7
XLogP3:10.9
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:14
Exact Mass:450.349780706
Monoisotopic Mass:450.349780706
Topological Polar Surface Area:34.1
Heavy Atom Count:33
Complexity:696
Undefined Atom Stereocenter Count:2
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Provides fat-soluble vitamins required for daily physiological needs

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Fat-soluble vitamin injection (Ⅱ)
Ingredients	This product is a sterile emulsion containing vitamin A, vitamin D, vitamin E, vitamin K, soybean oil for injection, lecithin, etc.
Indication	The vitamin K1 contained in this product may interact with coumarin anticoagulants.
Specifications	10ml
Manufacturer	Feisenyuskabi Huarui Pharmaceutical Co., Ltd.

ROSE- oil_oil
Manufacturer	Shenzhen Xiaomai Manufacturing Co., Ltd.

Recommended Suppliers of Vitamin K

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Vitamin Vitamin K with Phylloquinone Biological Activity 99% viscous liquid (cas:12001-79-5)

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