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Balofloxacin

Balofloxacin structure

CAS No:
127294-70-6
Formula:
C20H24FN3O4
Chemical Name:
Balofloxacin
Synonyms:
3-Quinolinecarboxylic acid,1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-(methylamino)-1-piperidinyl]-4-oxo-;1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-(methylamino)-1-piperidinyl]-4-oxo-3-quinolinecarboxylic acid;Q 35 (pharmaceutical);(±)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-(methylamino)piperidino]-4-oxo-3-quinolinecarboxylic acid;Balofloxacin;Q 35;Balorain;1-Cyclopropyl-6-fluoro-8-methoxy-7-[3-(methylamino)piperidin-1-yl]-4-oxoquinoline-3-carboxylic acid;165619-85-2
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Crystalline SolidBalofloxacin, a novel orally-active fluoroquinolone antibiotic, was introduced in South Korea for the treatment of urinary tract infections (UTI). It can be synthetized by reaction of 3-(methylamino)piperidine with the classical 4-quinolone-3-carboxylic acid template. In vitro antibacterial activity of balofloxacin against gram-positive bacteria (Staphylococcus aureus including methicillin-resistant S. aureus, Staphylococcus epidermis, Streptococcus pneumonia, Streptococcu

Balofloxacin Basic Attributes

Molecular Weight：

389.42

Exact Mass：

389.42

EC Number：

1312995-182-4

DSSTox ID：

DTXSID5046695

HScode：

2933990090

Characteristics

PSA：

82.1

XLogP3：

0.6

Density：

1.40±0.1 g/cm3(Predicted)

Melting Point：

137°C

Boiling Point：

608.3±55.0 °C(Predicted)

Flash Point：

321.7±31.5 °C

Refractive Index：

1.639

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)

MeSH Entry Terms：

1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methylaminopiperidine-1-yl)-4-oxoquinoline-3-carboxylic acid

Balofloxacin Use and Manufacturing

Balofloxacin is quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase.

Computed Properties

Molecular Weight:389.4
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:389.17508442
Monoisotopic Mass:389.17508442
Topological Polar Surface Area:82.1
Heavy Atom Count:28
Complexity:668
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

No specific pharmacological effects mentioned

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Balofloxacin

Balofloxacin Tablets
Ingredients	The main ingredient of this product is balofloxacin. Chemical name: 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methylamino-1-piperidinyl)-4-oxo-3-quinolinecarboxylic acid dihydrate. Chemical structure: Molecular formula: C20H24FN3O42H2O Molecular weight: 425.46
Indication	1. Antacids containing metallic aluminum and magnesium will interfere with the absorption of quinolones, so they cannot be taken at the same time with this product; 2. Concurrent use with non-steroidal anti-inflammatory drugs may interfere with the absorption of this product and increase the risk of convulsions; 3. When quinolones are used in combination with theophylline, the level of theophylline in serum may increase, so the dose of theophylline should be reduced when this product is used in combination with theophylline.
Specifications	0.1 g

Balofloxacin
Manufacturer	Yangtze River Pharmaceutical Group Jiangsu HaiCi Biological Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Jiangsu YONGDA Pharmaceutical Co., Ltd.

China
Active
Shandong Luoxin Pharmaceutical Group HENGXIN Pharmaceutical Co., Ltd.

China
Active
Yangtze River Pharmaceutical Group Jiangsu HaiCi Biological Pharmaceutical Co., Ltd.

China
Active

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