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Abacavir

Abacavir structure

CAS No:
136470-78-5
Formula:
C14H18N6O
Chemical Name:
Abacavir
Synonyms:
2-Cyclopentene-1-methanol,4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-,(1S,4R)-;2-Cyclopentene-1-methanol,4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-,(1S-cis)-;(1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol;Abacavir;1592U89;ABC;(-)-Abacavir
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Abacavir is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. IC50 value:Target: NRTI; reverse transcriptase inhibitorAbacavir is a nucleoside reverse transcriptase inhibitor marketed since 1999 for the treatment of infection with the human immunodeficiency virus type 1 (HIV). Despite its clinical efficacy, abacavir administration has been associated with serious and sometimes fatal toxic events. Abacavir has been reported to undergo bioactiv

Abacavir Basic Attributes

Molecular Weight：

286.33

Exact Mass：

286.33

EC Number：

1312995-182-4

NSC Number：

742406

Characteristics

PSA：

102

XLogP3：

1.1

Appearance：

Solid

Density：

1.7±0.1 g/cm3

Melting Point：

165°

Boiling Point：

636.0±65.0 °C at 760 mmHg

Flash Point：

338.4±34.3 °C

Refractive Index：

1.864

Water Solubility：

1.21e+00 g/L

Storage Conditions：

Refrigerator

Vapor Pressure：

4.77E-17mmHg at 25°C

Specific rotation：

D20 -59.7°; 43620 -127.8°; 36520 -218.1° (c = 0.15 in methanol)

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 2810

hazard class code：

R21:Harmful in contact with skin. R23/25:Toxic by inhalation and if swallowed . R43:May cause sensitization by skin contact. R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .

safety instructions：

S36/37-S45-S60-S61

RTECS Number：

GY5979200

Marks：

T,N

Precautionary statement(s)：

P201, P202, P261, P272, P280, P281, P302+P352, P305+P351+P338, P308+P313, P310, P321, P333+P313, P363, P405, P501

Hazard Statements：

H317

Abacavir Use and Manufacturing

A nucleoside reverse transcriptase inhibitor (NRTI).

Computed Properties

Molecular Weight:286.33
XLogP3:0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:286.15420922
Monoisotopic Mass:286.15420922
Topological Polar Surface Area:102
Heavy Atom Count:21
Complexity:414
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It is converted into the active metabolite carbavir triphosphate (CBV-TP) by intracellular enzymes. CBV-TP inhibits the activity of HIV-1 reverse transcriptase (RT) by competing with the natural substrate dGTP and inserting into viral DNA.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Abacavir and Lamivudine Tablets
Specifications	Each tablet contains 600 mg of abacavir (sulfate) and 300 mg of lamivudine

Dotiabalamil tablets
Ingredients	This product is a compound preparation. Each tablet contains 50 mg of dolutegravir sodium (calculated as dolutegravir), 600 mg of abacavir sulfate (calculated as abacavir) and 300 mg of lamivudine.
Indication	This product contains dolutegravir, abacavir, and lamivudine, so the interactions found when these drugs are used alone are related to this product. No clinically significant drug interactions are expected between dolutegravir, abacavir, and lamivudine.
Specifications	50mg/600mg/300mg x 30 tablets

Abacavir and diavudine tablets
Specifications	Each tablet contains 300 mg of abacavir sulfate (calculated as abacavir), 150 mg of lamivudine and 300 mg of zidovudine.

See More Related Drugs

Registered Holders

DR. REDDYS LABORATORIES LTD.

Philippines
Active

Recommended Suppliers of Abacavir

Dayang Chem (Hangzhou) Co.,Ltd Contact Supplier

CN
3 YRS

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Abacavir Manufacturer/High quality/Best price/In stock

CAS No.: 136470-78-5

Grade: Industrial Grade

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CN
5 YRS

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Abacavir

CAS No.: 136470-78-5

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