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Iobitridol

Iobitridol structure

CAS No:
136949-58-1
Formula:
C20H28I3N3O9
Chemical Name:
Iobitridol
Synonyms:
1,3-Benzenedicarboxamide,N1,N3-bis(2,3-dihydroxypropyl)-5-[[3-hydroxy-2-(hydroxymethyl)-1-oxopropyl]amino]-2,4,6-triiodo-N1,N3-dimethyl-;1,3-Benzenedicarboxamide,N,N′-bis(2,3-dihydroxypropyl)-5-[[3-hydroxy-2-(hydroxymethyl)-1-oxopropyl]amino]-2,4,6-triiodo-N,N′-dimethyl-;N1,N3-Bis(2,3-dihydroxypropyl)-5-[[3-hydroxy-2-(hydroxymethyl)-1-oxopropyl]amino]-2,4,6-triiodo-N1,N3-dimethyl-1,3-benzenedicarboxamide;Iobitridol;Xenetix;Optiject
Categories:
Active Pharmaceutical Ingredients > Diagnostic Agents

Description

White to Off-White SolidChEBI: A benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and a 3-hydroxy-2-(hydroxymethyl)propanimido at position 5.

Iobitridol is a benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and a 3-hydroxy-2-(hydroxymethyl)propanimido at position 5. It has a role as a xenobiotic, an environmental contaminant and a radioopaque medium. It is an organoiodine compound, a hexol and a benzenedicarboxamide.|Iobitridol has been used in trials studying the diagnostic of Diagnostic Imaging, Coronary Artery Disease, Type 2 Diabetes Mellitus, and Coronary Atherosclerosis.|Iobitridol is a water-soluble, tri-iodinated, non-ionic monomeric benzoate derivative and contrast medium used in diagnostic radiography. Upon administration, iobitridol is distributed through the vascular system and interstitial space. Like other organic iodine compounds, this agent blocks x-rays and appears opaque on x-ray film thus, enhancing the visibility of body parts containing this agent. Iobitridol is rapidly removed by the kidneys in an unchanged form, and in cases of renal failure, heterotropic excretion occurs via the biliary route.

Iobitridol Basic Attributes

Molecular Weight：

835.153

Exact Mass：

835.16

UNII：

182ECH14UH

NCI Thesaurus Code：

C83821

ATC Code：

V08AB11|V - Various

Characteristics

PSA：

191

XLogP3：

-3.23

Density：

2.171±0.06 g/cm3(Predicted)

Melting Point：

196-199°C

Boiling Point：

1010.9±65.0 °C(Predicted)

Flash Point：

565.2±34.3 °C

Refractive Index：

1.726

Storage Conditions：

Refrigerator

Vapor Pressure：

0mmHg at 25°C

Toxicity：

LD50 in male, female mice (g I/kg): 16.8, 16.6 i.v. (Donadieu)

Drug Information

MeSH：

Substances used to allow enhanced visualization of tissues. (See all compounds classified as Contrast Media.)

MeSH Entry Terms：

5-(3-hydroxy-2-hydroxymethylpropionamido)-N,N'-dimethyl-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide

Iobitridol Use and Manufacturing

Diagnostic aid (radiopaque medium).

Computed Properties

Molecular Weight:835.2
XLogP3:-3
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:12
Exact Mass:834.8960
Monoisotopic Mass:834.8960
Topological Polar Surface Area:191
Heavy Atom Count:35
Complexity:675
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Contrast agents

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Iobitol Injection
Specifications	50 ml: 15 g (I)

Iobitol Injection
Specifications	100 ml: 30 g (I)

Iobitol Injection
Specifications	50 ml: 17.5 g (I)

See More Related Drugs

Registered Holders

Sichuan Ren An Pharmaceutical Co., Ltd.

China
Active
Chongqing Shenghuaxi Pharmaceutical. Co., Ltd.

China
Active
Zhejiang Hichi Pharmaceutical Corporation Limited

China
Inactive

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