Goserelin acetate
-
Goserelin acetate
structure -
-
CAS No:
145781-92-6
-
Formula:
C59H84N18O14
-
Chemical Name:
Goserelin acetate
-
Synonyms:
PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZAGLY-NH2;[(T-BU)DSER6, (AZA)GLY10]-LH-RH;[(T-BU)DSER6, (AZA)GLY10]-LUTEINIZING HORMONE-RELEASING HORMONE;GLP-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZA-GLY-NH2;(D-SER(TBU)6,AZAGLY10)-LHRH;(D-Ser(tBu)6,Azagly10)-LHRH acetate salt;Goserelin HCl;GOSERELIN HCL[PYR-HIS-TRP-SER-TYR-D-SER(T-BU)-LEU-ARG-PRO-AZAGLY-NH2]
-
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System
-
CAS No:
Characteristics
493.39000
-0.95
white powder
1.5±0.1 g/cm3
>190°C (dec.)
1695.5ºC at 760mmHg
1.692
H2O: 20 mg/mL, clear, colorless
−20°C
Goserelin acetate Use and Manufacturing
Synthetic peptide agonist analog of LH-RH. Antineoplastic (hormonal).
Drug Function and Efficacy
This drug is a synthetic analog of luteinizing hormone-releasing hormone. Long-term use can inhibit the secretion of luteinizing hormone from the pituitary gland, thereby causing a decrease in male serum testosterone and female serum estradiol. This effect is reversible after discontinuation of the drug. About 21 days after the first dose of the drug, the testosterone concentration of male patients can be reduced to the level after castration. During the treatment process of taking the drug once every 28 days, the testosterone concentration has been maintained within the concentration range after castration. This testosterone inhibition can cause prostate tumors to regress and symptoms to improve in most patients. About 21 days after the first dose of the drug, the serum estradiol concentration of female patients is suppressed and maintained at the postmenopausal level during the subsequent 28-day treatment. This inhibition is associated with hormone-dependent breast cancer and endometriosis.
Registered Holders
-
AstraZeneca Pharmaceuticals LP
Active
United States
-
Bachem AG
Active
Switzerland
-
Chinese Peptide Co., Ltd.
Active
China
Recommended Suppliers of Goserelin acetate
-
![China]()
CN
4 YRS
Business licensedTrader Supplier of S3,14 bd0InquiryUnit Price: $0.8-1 /G FOBCAS No.: 145781-92-6Grade: Pharmaceutical GradeContent: 99% -
![China]()
CN
5 YRS
Business licensed Certified factoryManufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive -
![China]()
CN
4 YRS
Business licensedTrader Supplier of additives,pharmaceutical chemicals,organic intermediate,chemical intermediates,Pharmaceutical Intermediates,catalyst,APIInquiryCAS No.: 145781-92-6Grade: Pharmaceutical gradeContent: 99% -
![China]()
CN
7 YRS
Business licensed Certified factoryManufactory Supplier of CMO,GMP Peptides,API,Cosmetic Peptides,CRO,Custom Peptides -
![China]()
CN
4 YRS
Business licensed Certified factoryManufactory Supplier of PEPTIDE
Learn More Other Chemicals
-
Cyclooctenol, acetate
93981-85-2
-
Pyridinium, 1-[2-[[4-[2-(2,6-dichloro-4-nitrophenyl)diazenyl]phenyl]ethylamino]ethyl]-, acetate (1:1)
59709-07-8
-
(Z)-6-Nonen-1-yl acetate
76238-22-7
-
(2,4-dichloro-6-nitrophenyl) acetate Formula
37169-10-1
-
[Bis(2,2-dimethyl-1-aziridinyl)phosphinyl](ethoxycarbonyl)azanyl acetate Formula
54805-59-3
-
2-methylidenebutyl acetate Formula
55670-09-2
-
(3-acetyl-2,5-dioxo-4,4-diphenylimidazolidin-1-yl) acetate Structure
56775-94-1
-
[3-acetyloxy-2-[2-(cyclohexylamino)-2-oxoethyl]-1-benzofuran-6-yl] acetate Structure
60722-34-1
-
What is [3-acetyloxy-2-(2-amino-2-oxoethyl)-1-benzofuran-6-yl] acetate
60722-26-1
-
What is [3-[1-acetyloxy-2-(methylamino)ethyl]phenyl] acetate
63991-22-0