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Indinavir

Indinavir structure

CAS No:
150378-17-9
Formula:
C36H47N5O4
Chemical Name:
Indinavir
Synonyms:
D-erythro-Pentonamide,2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-;D-erythro-Pentonamide,2,3,5-trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-[2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-,[1(1S,2R),5(S)]-;2,3,5-Trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide;Indinavir;Compound J;166746-42-5;216884-06-9
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Crixivan was launched in Australia, Switzerland, the UK and the US as an orally-bioavailable HIV-1 protease inhibitor. The compound can be prepared by coupling an optically active piperazine derivative with an epoxide derivative (now commercially available). The synthesis of the proteins, reverse transcriptase, integrase, structural proteins and a protease, required by the virus to complete its lifecycle, can be interupted if the protease enzyme is not capable of cleaving a proform polype

Indinavir Basic Attributes

Molecular Weight：

613.79

Exact Mass：

613.79

Characteristics

PSA：

118

XLogP3：

2.9

Appearance：

Solid

Density：

1.25±0.1 g/cm3(Predicted)

Melting Point：

153-154°; mp 167.5-168°

Boiling Point：

877.9±65.0 °C(Predicted)

Flash Point：

456.8±37.1 °C

Refractive Index：

1.629

Water Solubility：

4.82e-02 g/L

Storage Conditions：

Commercially available indinavir sulfate capsules should be stored at 15-30C in a tight container. Indinavir sulfate capsules must be protected from moisture; the capsules should be stored in the manufacturer-provided bottle and the desiccant should not be removed from the bottle.

Vapor Pressure：

0mmHg at 25°C

Specific rotation：

D22 +24.1° (c = 0.0133 in chloroform)

Indinavir Use and Manufacturing

Indinavir is a member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors. Indinavir is used as an antiviral.