Sitafloxacin Sesquihydrate
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Sitafloxacin Sesquihydrate
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CAS No:
163253-35-8
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Formula:
C19H20ClF2N3O4
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Chemical Name:
Sitafloxacin Sesquihydrate
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Synonyms:
Sitafloxacin hydrate;Sitafloxacin Sesquihydrate;7-[(7S)-7-Amino-5-azaspiro[2.4]heptan-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrate (2:3);3-Quinolinecarboxylic acid, 7-((7S)-7-amino-5-azaspiro(24)hept-5-yl)-8-chloro-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-1,4-dihydro-4-oxo-, hydrate (2:3);3-Quinolinecarboxylic acid, 7-(7-amino-5-azaspiro(24)hept-5-yl)-8-chloro-6-fluoro-1-(2-fluorocyclopropyl)-1,4-dihydro-4-oxo-, hydrate (2:3), (1R-(1alpha(S*),2alpha))-;Du 6859a;Unii-9td681796g;Sitafloxacin hydrate (2:3)
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Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs
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CAS No:
Description
Off-White Solid
The fluoroquinolone antibacterial agent sitafloxacin hydrate was developed by Daiichi Sankyo and was approved and launched last year in Japan. Sitafloxacin’s mode of action is through inhibition of DNA gyrase and topoisomerase IV. It is indicated for the treatment of inflammatory infections such as laryngopharyngitis, adenoiditis, acute bronchitis, pneumonia, secondary infections due to chronic respiratory lesions, cystitis, pyelonephritis, urethritis, cervicitis, otitismedia, sinusitis, periodontitis, and pericoronitis and jaw inflammation. Due to its broad spectrum of potent antibacterial activity, sitafloxacin is expected to be clinically effective in treating severe cases of bacterial infection, relapse/recrudescence of infection and infections in which resistant bacteria are suspected to be the cause.
Sitafloxacin Sesquihydrate Basic Attributes
427.83
409.100476
1308068-626-2
White to Off-White
2941900000
Characteristics
86.9
3.40360
145-147°C (dec.)
629.2°C at 760 mmHg
334.3ºC
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
1.06E-16mmHg at 25°C
589 -199.9°
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
Sitafloxacin Sesquihydrate Use and Manufacturing
Antibacterial
Sitafloxacin is a new-generation, broad-spectrum oral fluoroquinolone antibiotic. It is very active against many Gram-positive, Gram-negative and anaerobic clinical isolates, including strains resistant to other fluoroquinolones, was recently approved in
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