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Vitamin E nicotinate

Vitamin E nicotinate structure

CAS No:
16676-75-8
Formula:
C35H53NO3
Chemical Name:
Vitamin E nicotinate
Synonyms:
tocopherylnicotinate,vitaminenicotinate;ALPHA-TOCOPHERYL NICOTINATE;[2,5,7,8-TETRAMETHYL-2-(4,8,12-TRIMETHYLTRIDECYL)CHROMAN-6-YL] PYRIDINE-3-CARBOXYLATE;1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester;(+/-)-alpha-Tocopherol nicotinate;Vitamin E nicotinate;[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] pyridine-3-carboxylate;nicotin [(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-yl] ester
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Vitamin E nicotinate is a compound formed by the esterification of vitamin E and niacin. It has the functions of activating the microcirculation system, softening blood vessels, inhibiting platelet aggregation, reducing blood viscosity, and increasing blood oxygen partial pressure. Also Vitamin E nicotinate can improve lipid metabolism, effectively reduce triglycerides, cholesterol and lipid peroxides, increase high-density lipoprotein, and comprehensively regulate blood lipid levels.

ChEBI: Tocopheryl nicotinate is a tocol.

Vitamin E nicotinate Basic Attributes

Molecular Weight：

535.8

Exact Mass：

535.80

EC Number：

605-452-8

Characteristics

PSA：

48.4

XLogP3：

13.23

Density：

1.0±0.1 g/cm3

Boiling Point：

649.0±55.0 °C at 760 mmHg

Flash Point：

346.3±31.5 °C

Refractive Index：

1.514

Storage Conditions：

2-8°C

Critical Temperature & Pressure：

2-8°C

Safety Information

wgk germany：

Vitamin E nicotinate Use and Manufacturing

This product is a peripheral vasodilator. It can directly act on the blood vessel wall, has the effect of promoting blood circulation, continuously and steadily increasing blood flow, and can inhibit the biosynthesis of cholesterol. It is used for hypertension, cerebral arteriosclerosis, cerebral stroke, concussion and sequelae of brain trauma, headache, dizziness, central retinitis and other vascular disorders. It can also be used for abnormal lipid metabolism, coronary artery insufficiency and circulatory disorders.

Drug Function and Efficacy

Vitamin E is an antioxidant that can combine with selenium in the diet to prevent free radical damage to polyunsaturated fatty acids in membranes and other cell structures, protect red blood cells from hemolysis, protect nerves and muscles from oxygen free radical damage, maintain normal development and function of nerves and muscles, and may also be a cofactor for certain enzyme systems. Niacin is converted into nicotinamide in the body, and then combined with riboadenine to form nicotinamide adenine dinucleotide (coenzyme I) and nicotinamide adenine dinucleotide phosphate (coenzyme II), which are necessary for lipid, amino acid, protein, purine metabolism, tissue respiration oxidation and glycogenolysis. Niacin can reduce the utilization of coenzyme A and affect the transportation of cholesterol in the blood by inhibiting the synthesis of very low-density lipoprotein (VLDL).

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Vitamin E Nicotinate Capsules
Ingredients	Vitamin E nicotinate.
Indication	1 Large amounts of aluminum hydroxide can precipitate bile acid in the upper small intestine and reduce the absorption of fat-soluble vitamin E. 2. Avoid using coumarin and its derivatives with large amounts of vitamin E to prevent the occurrence of hypoprothrombinemia. 3 Lipid-lowering drugs such as cholestyramine and colestipol, mineral oil and sucralfate can interfere with the absorption of vitamin E. 4 The need for vitamin E increases when iron is supplemented for iron-deficiency anemia. 5 Vitamin E can promote the absorption of vitamin A, increase the storage and utilization of vitamin A in the liver, and reduce the occurrence of vitamin A poisoning; but when exceeded, it can reduce the storage of vitamin A in the body. 6 Isoniazid can prevent niacin from binding to coenzyme I, resulting in a decrease in niacin. 7 When niacin is used in combination with adrenergic receptor blocking antihypertensive drugs such as guanethidine, its vasodilatory effect is synergistically enhanced, and direct hypotension can occur.
Specifications	0.1g

Vitamin E Nicotinate Capsules
Ingredients	Vitamin E nicotinate.
Indication	1 Large amounts of aluminum hydroxide can precipitate bile acid in the upper small intestine and reduce the absorption of fat-soluble vitamin E. 2. Avoid using coumarin and its derivatives with large amounts of vitamin E to prevent the occurrence of hypoprothrombinemia. 3 Lipid-lowering drugs such as cholestyramine and colestipol, mineral oil and sucralfate can interfere with the absorption of vitamin E. 4 The need for vitamin E increases when iron is supplemented for iron-deficiency anemia. 5 Vitamin E can promote the absorption of vitamin A, increase the storage and utilization of vitamin A in the liver, and reduce the occurrence of vitamin A poisoning; but when exceeded, it can reduce the storage of vitamin A in the body. 6 Isoniazid can prevent niacin from binding to coenzyme I, resulting in a decrease in niacin. 7 When niacin is used in combination with adrenergic receptor blocking antihypertensive drugs such as guanethidine, its vasodilatory effect is synergistically enhanced, and direct hypotension can occur.
Specifications	0.1g
Manufacturer	Tonghua Zhongsheng Pharmaceutical Co., Ltd.

Vitamin E Nicotinate Capsules
Ingredients	Vitamin E nicotinate.
Indication	1 Large amounts of aluminum hydroxide can precipitate bile acid in the upper small intestine and reduce the absorption of fat-soluble vitamin E. 2. Avoid using coumarin and its derivatives with large amounts of vitamin E to prevent the occurrence of hypoprothrombinemia. 3 Lipid-lowering drugs such as cholestyramine and colestipol, mineral oil and sucralfate can interfere with the absorption of vitamin E. 4 The need for vitamin E increases when iron is supplemented for iron-deficiency anemia. 5 Vitamin E can promote the absorption of vitamin A, increase the storage and utilization of vitamin A in the liver, and reduce the occurrence of vitamin A poisoning; but when exceeded, it can reduce the storage of vitamin A in the body. 6 Isoniazid can prevent niacin from binding to coenzyme I, resulting in a decrease in niacin. 7 When niacin is used in combination with adrenergic receptor blocking antihypertensive drugs such as guanethidine, its vasodilatory effect is synergistically enhanced, and direct hypotension can occur.
Specifications	0.1g

See More Related Drugs

Registered Holders

Hainan Wuren Pharmaceutical Co., Ltd.

China
Active
Second PHARMA Co., Ltd.

China
Active
Zhejiang Kinglyuan Pharmaceutical Co., Ltd.

China
Active

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Vitamin E nicotinate

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