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Peramivir

Peramivir structure

CAS No:
229614-55-5
Formula:
C15H28N4O4
Chemical Name:
Peramivir
Synonyms:
(1S,2S,3R,4R)-3-(1-acetaMido-2-ethylbutyl)-4-guanidino-2-hydroxycyclopentanecarboxylic acid;3(R)-[1(S)-AcetaMido-2-ethylbutyl]-4(R)-guanidino-2(S)- hydroxycyclopentane-1(S)-carboxylic acid;PERAMIVIRUM;(1S,2S,3S,4R)-3-[(1S)-1-AcetaMido-2-ethylbutyl]-4-[(diaMinoMethylene)aMino]-2-hydroxycyclopentanecarboxylic acid;(1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid;(1R,2R,3S,4S)-3-((R)-1-acetamido-2-ethylbutyl)-4-guanidino-2-hydroxycyclopentane-1-carboxylic acid;Peramivir USP/EP/BP;Peramivirr
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

ChEBI: Peramivir is a member of the class of guanidines that is used (as its trihydrate) for the treatment of acute uncomplicated influenza in patients 18 years and older who have been symptomatic for no more than two days. It has a role as an antiviral drug and an EC 3.2.1.18 (exo-alpha-sialidase) inhibitor. It is a member of cyclopentanols, a member of acetamides, a member of guanidines and a 3-hydroxy monocarboxylic acid. It contains a peramivir hydrate.

Peramivir Basic Attributes

Molecular Weight：

328.41

Exact Mass：

328.41

EC Number：

1308068-626-2

Characteristics

PSA：

148.53000

XLogP3：

-1.37

Density：

1.4±0.1 g/cm3

Refractive Index：

1.614

Peramivir Use and Manufacturing

A new antiviral agent for influenza treatment; it can be used as neuraminidase inhibitor for treating human and avian influenza

Drug Function and Efficacy

Peramivir is a cyclopentane anti-influenza virus drug that can bind to the active site of influenza virus neuraminidase and has inhibitory activity against human influenza A and B viruses. Biochemical analysis showed that peramivir could inhibit the neuraminidase activity of several influenza A and B virus strains, with a median ICso value of 0.2nM (0.09~1.4nM, n=15) for influenza A virus strains, a median ICco value of 1.3nM (0.06~11nM, n=8) for influenza B virus strains, and an ICso value range of 0.06~0.26nM for 2009 HINIA influenza virus strains (swine flu). The antiviral activity of peramivir against laboratory virus strains and clinically isolated virus strains was investigated in cell culture experiments. The ECs0 value for seasonal influenza A HIN1 strain is 1μM (0.09~21μM, n=5), the ECso value for influenza A H3N2 strain is 0.07μM (0.01~0.16μM, n=12), and the ECso value for influenza B strain is 2.2μM (0.06~3.2uM, n=5). Limited biochemical analysis, cell culture and animal model data show that the antiviral activity of peramivir and oseltamivir is synergistic.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Peramivir
Manufacturer	HNG Chambio Trading Co., Ltd.

Peramivir Sodium Chloride Injection
Ingredients	The main ingredient of this product is peramivir, and the excipients used are sodium chloride and dilute hydrochloric acid
Indication	Pharmacokinetic study data show that peramivir is not degraded in vivo and is excreted almost in its original form through the kidneys. It has a low protein binding rate, indicating that drug interactions related to protein binding are unlikely to occur. In vitro studies have shown that P450 enzymes are not involved in the metabolism of peramivir: peramivir does not inhibit the activity of hepatic cytochrome P450 drug metabolizing enzymes 3A4 and 2D6. Peramivir has a certain induction effect on the production of rat CYP3 enzymes, but the induction effect is not strong. At present, drug interaction studies of peramivir injection and co-administration trials with other drugs have not been carried out. Be cautious when used in combination with other drugs eliminated by the kidneys, and be cautious when used in combination with drugs that are also secreted by the kidneys and have a narrow safety range (such as chlorpropamide, methotrexate, and phenylbutazone), and monitor the patient's renal function appropriately. There is no evaluation of the interaction between peramivir and live attenuated influenza vaccines. However, due to the possible interaction between the two, unless clinically necessary, peramivir should not be used within two weeks of using live attenuated influenza vaccines, and live attenuated influenza vaccines should not be used within 48 hours after using peramivir. Because peramivir, as an antiviral drug, may inhibit the replication of live vaccine viruses, the trivalent inactivated influenza vaccine can be used at any time before or after the administration of peramivir.
Specifications	100ml: Peramivir (calculated as C15H28N4O4) 0.3g and sodium chloride 0.9g
Manufacturer	Guangzhou Nucien Pharmaceutical Co., Ltd.

Peramivir Sodium Chloride Injection
Ingredients	The main ingredient of this product is peramivir, and the excipients used are sodium chloride and dilute hydrochloric acid
Indication	Pharmacokinetic study data show that peramivir is not degraded in vivo and is excreted almost in its original form through the kidneys. It has a low protein binding rate, indicating that drug interactions related to protein binding are unlikely to occur. In vitro studies have shown that P450 enzymes are not involved in the metabolism of peramivir: peramivir does not inhibit the activity of hepatic cytochrome P450 drug metabolizing enzymes 3A4 and 2D6. Peramivir has a certain induction effect on the production of rat CYP3 enzymes, but the induction effect is not strong. At present, drug interaction studies of peramivir injection and co-administration trials with other drugs have not been carried out. Be cautious when used in combination with other drugs eliminated by the kidneys, and be cautious when used in combination with drugs that are also secreted by the kidneys and have a narrow safety range (such as chlorpropamide, methotrexate, and phenylbutazone), and monitor the patient's renal function appropriately. There is no evaluation of the interaction between peramivir and live attenuated influenza vaccines. However, due to the possible interaction between the two, unless clinically necessary, peramivir should not be used within two weeks of using live attenuated influenza vaccines, and live attenuated influenza vaccines should not be used within 48 hours after using peramivir. Because peramivir, as an antiviral drug, may inhibit the replication of live vaccine viruses, the trivalent inactivated influenza vaccine can be used at any time before or after the administration of peramivir.
Specifications	100 ml: Peramivir (calculated as C15H28N4O4) 0.15 g and sodium chloride 0.9 g
Manufacturer	Guangzhou Nucien Pharmaceutical Co., Ltd.

Registered Holders

Zein BIOTECHNOLOGY Co., Ltd.

China
Active
Porton Pharma Solutions Ltd.

China
Active
TianJin TaiPu Pharmaceutical Co., Ltd.

China
Active

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