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Carbetapentane citrate

Carbetapentane citrate structure

CAS No:
23142-01-0
Formula:
C20H31NO3.C6H8O7
Chemical Name:
Carbetapentane citrate
Synonyms:
Cyclopentanecarboxylic acid,1-phenyl-,2-[2-(diethylamino)ethoxy]ethyl ester,2-hydroxy-1,2,3-propanetricarboxylate (1:1);Cyclopentanecarboxylic acid,1-phenyl-,2-[2-(diethylamino)ethoxy]ethyl ester citrate (1:1);Toclase;Carbetapentane citrate;Sedotussin;Pentoxyverine citrate;Tosnore;Calnathal;Antees;Tuclase;Fustpentane;Pencal;Carbetane;Germapect;Cossym;UCB 2543;2-(2-(Diethylamino)ethoxy)ethyl 1-phenylcyclopentanecarboxylate 2-hydroxypropane-1,2,3-tricarboxylate;5585-88-6
Categories:
Active Pharmaceutical Ingredients > Respiratory Drugs

Description

Carbetapentane citrate is a selective inhibitor of the cough, with mild atropine-like effect and local anesthesia effect.

Carbetapentane citrate is a carbonyl compound.

Carbetapentane citrate Basic Attributes

Molecular Weight：

525.59

Exact Mass：

525.257385

EC Number：

245-449-5

UNII：

4SH0MFJ5HJ

NSC Number：

757833

DSSTox ID：

DTXSID10177717

HScode：

2922509090

Characteristics

PSA：

171

XLogP3：

2.15150

Appearance：

White to off-white solid

Melting Point：

93 °C

Boiling Point：

435.5ºC at 760mmHg

Flash Point：

217.2ºC

Water Solubility：

H2O: soluble

Storage Conditions：

Store at RT

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22-36/37/38

safety instructions：

26-36

RTECS Number：

GY3500000

Marks：

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H302-H312-H315-H319-H332-H335

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 76 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents.)

MeSH Entry Terms：

2-(2-diethylaminoethoxy)ethyl 1-phenylcyclopentyl-1-carboxylate

Carbetapentane citrate Use and Manufacturing

An over-the-counter cough suppressant.

Computed Properties

Molecular Weight:525.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:16
Exact Mass:525.25739644
Monoisotopic Mass:525.25739644
Topological Polar Surface Area:171
Heavy Atom Count:37
Complexity:583
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product has central and peripheral antitussive effects, and its antitussive effect strength is about 1/3 of codeine. In addition to having a direct inhibitory effect on the respiratory center of the medulla oblongata, it also has a mild atropine-like effect. It can relax spasmodic bronchial smooth muscles and reduce airway resistance.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Pentotheline Citrate Tablets
Ingredients	Pentoxetine citrate.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	25mg
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Guaifenpentol promethazine granules
Ingredients	This product is a compound preparation, each package contains 5 mg of promethazine hydrochloride, 125 mg of potassium guaiacol sulfonate, and 10 mg of pentoxyverine citrate.
Indication	1. This product can increase the inhibitory effect on the central nervous system when used with central nervous system sedatives, hypnotics or ethanol. 2. This product should not be used with antihypertensive drugs or antidepressants. 3. If used with other drugs at the same time, drug interactions may occur. Please consult a doctor or pharmacist for details.
Specifications	Compound
Manufacturer	Sichuan Shuangxin Pharmaceutical Co., Ltd.

Guaifenpentol promethazine granules
Ingredients	This product is a compound preparation, each package contains 5 mg of promethazine hydrochloride, 125 mg of potassium guaiacol sulfonate, and 10 mg of pentoxyverine citrate.
Indication	1. This product can increase the inhibitory effect on the central nervous system when used with central nervous system sedatives, hypnotics or ethanol. 2. This product should not be used with antihypertensive drugs or antidepressants. 3. If used with other drugs at the same time, drug interactions may occur. Please consult a doctor or pharmacist for details.
Specifications	Compound
Manufacturer	Fujian Quanzhou Hengda Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Shanghai Shourusong Pharmaceutical Industry Miyang Pharmaceutical Co., Ltd.

China
Active
Henan Purui MEDICINE Co., Ltd.

China
Active
Zenji Pharmaceuticals (SuZhou) Ltd

China
Active

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